Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling

Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling

Abstract Background Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy. Methods The primary hippocampal neurons, N2a and HEK293T cells with...

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Bibliographic Details
Main Authors: Meng-Zhu Li, En-Jie Liu, Qiu-Zhi Zhou, Shi-Hong Li, Shi-Jie Liu, Hai-Tao Yu, Qi-Hang Pan, Fei Sun, Ting He, Wei-Jin Wang, Dan Ke, Yu-Qi Feng, Jun Li, Jian-Zhi Wang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Military Medical Research
Subjects:
Tau
Autophagy
Amino acid pathway
Mammalian target of rapamycin kinase complex 1 (mTORC1)
T cell intracellular antigen 1 (TIA1)
Online Access:https://doi.org/10.1186/s40779-022-00396-x

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