Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway

Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway

Abstract Background Ferroptosis plays an essential role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). Meteorin-like/Meteorin-β (Metrnβ) is a protein secreted by skeletal muscle and adipose tissue and plays a role in cardiovascular diseases. However, its role in acute lung injury has n...

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Bibliographic Details
Main Authors: Zhen Chen, Jun Li, Huan Peng, Mengli Zhang, Xian Wu, Feng Gui, Wei Li, Fen Ai, Bo Yu, Yijue Liu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Molecular Medicine
Subjects:
Metrnβ
Acute lung injury
SIRT1
Ferroptosis
SLC7A11
Online Access:https://doi.org/10.1186/s10020-023-00714-6

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