Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention
<b>Background:</b> Elevated circulating plasma levels of both lipopolysaccharide-binding protein (LBP) and chemerin are reported in patients with obesity, but few studies are available on lifestyle intervention programs. We investigated the association of both LBP and chemerin plasma lev...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/289 |
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| author | Amelia Marti Isabel Martínez Ana Ojeda-Rodríguez María Cristina Azcona-Sanjulian |
| author_facet | Amelia Marti Isabel Martínez Ana Ojeda-Rodríguez María Cristina Azcona-Sanjulian |
| author_sort | Amelia Marti |
| collection | DOAJ |
| description | <b>Background:</b> Elevated circulating plasma levels of both lipopolysaccharide-binding protein (LBP) and chemerin are reported in patients with obesity, but few studies are available on lifestyle intervention programs. We investigated the association of both LBP and chemerin plasma levels with metabolic syndrome (MetS) outcomes in a lifestyle intervention in children and adolescents with abdominal obesity <b>Methods</b>: Twenty-nine patients enrolled in a randomized controlled trial were selected. The lifestyle intervention with a 2-month intensive phase and a subsequent 10-month follow-up consisted of a moderate calorie-restricted diet, recommendations to increase physical activity levels, and nutritional education. <b>Results:</b> Weight loss was accompanied by a significant reduction in MetS prevalence (−43%; <i>p</i> = 0.009). Chemerin (<i>p</i> = 0.029) and LBP (<i>p</i> = 0.033) plasma levels were significantly reduced at 2 months and 12 months, respectively. At the end of intervention, MetS components were associated with both LBP (<i>p</i> = 0.017) and chemerin (<i>p</i> < 0.001) plasma levels. <b>Conclusions</b>: We describe for the first time a reduction in both LBP and chemerin plasma levels and its association with MetS risk factors after a lifestyle intervention program in children and adolescents with abdominal obesity. Therefore, LBP and chemerin plasma levels could be used as biomarkers for the progression of cardiovascular risk in pediatric populations. |
| first_indexed | 2024-03-09T04:10:59Z |
| format | Article |
| id | doaj.art-c3d89ae22cf6494385212d516a5e156c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T04:10:59Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c3d89ae22cf6494385212d516a5e156c2023-12-03T14:01:03ZengMDPI AGNutrients2072-66432021-01-0113228910.3390/nu13020289Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle InterventionAmelia Marti0Isabel Martínez1Ana Ojeda-Rodríguez2María Cristina Azcona-Sanjulian3Department of Nutrition, Food Sciences and Physiology, University of Navarra, C/Irunlarrea, 31008 Pamplona, SpainDepartment of Nutrition, Food Sciences and Physiology, University of Navarra, C/Irunlarrea, 31008 Pamplona, SpainDepartment of Nutrition, Food Sciences and Physiology, University of Navarra, C/Irunlarrea, 31008 Pamplona, SpainIdiSNA, Instituto de Investigación Sanitaria de Navarra, C/Irunlarrea, 3, 31008 Pamplona, Spain<b>Background:</b> Elevated circulating plasma levels of both lipopolysaccharide-binding protein (LBP) and chemerin are reported in patients with obesity, but few studies are available on lifestyle intervention programs. We investigated the association of both LBP and chemerin plasma levels with metabolic syndrome (MetS) outcomes in a lifestyle intervention in children and adolescents with abdominal obesity <b>Methods</b>: Twenty-nine patients enrolled in a randomized controlled trial were selected. The lifestyle intervention with a 2-month intensive phase and a subsequent 10-month follow-up consisted of a moderate calorie-restricted diet, recommendations to increase physical activity levels, and nutritional education. <b>Results:</b> Weight loss was accompanied by a significant reduction in MetS prevalence (−43%; <i>p</i> = 0.009). Chemerin (<i>p</i> = 0.029) and LBP (<i>p</i> = 0.033) plasma levels were significantly reduced at 2 months and 12 months, respectively. At the end of intervention, MetS components were associated with both LBP (<i>p</i> = 0.017) and chemerin (<i>p</i> < 0.001) plasma levels. <b>Conclusions</b>: We describe for the first time a reduction in both LBP and chemerin plasma levels and its association with MetS risk factors after a lifestyle intervention program in children and adolescents with abdominal obesity. Therefore, LBP and chemerin plasma levels could be used as biomarkers for the progression of cardiovascular risk in pediatric populations.https://www.mdpi.com/2072-6643/13/2/289lifestyle interventionobese childrenchemerinmetabolic syndromelipopolysaccharide binding protein |
| spellingShingle | Amelia Marti Isabel Martínez Ana Ojeda-Rodríguez María Cristina Azcona-Sanjulian Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention Nutrients lifestyle intervention obese children chemerin metabolic syndrome lipopolysaccharide binding protein |
| title | Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention |
| title_full | Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention |
| title_fullStr | Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention |
| title_full_unstemmed | Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention |
| title_short | Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention |
| title_sort | higher lipopolysaccharide binding protein and chemerin concentrations were associated with metabolic syndrome features in pediatric subjects with abdominal obesity during a lifestyle intervention |
| topic | lifestyle intervention obese children chemerin metabolic syndrome lipopolysaccharide binding protein |
| url | https://www.mdpi.com/2072-6643/13/2/289 |
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