Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-ind...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14556 |
| _version_ | 1818977907013320704 |
|---|---|
| author | Mauricio D. Dorfman Jordan E. Krull John D. Douglass Rachael Fasnacht Fernando Lara-Lince Thomas H. Meek Xiaogang Shi Vincent Damian Hong T. Nguyen Miles E. Matsen Gregory J. Morton Joshua P. Thaler |
| author_facet | Mauricio D. Dorfman Jordan E. Krull John D. Douglass Rachael Fasnacht Fernando Lara-Lince Thomas H. Meek Xiaogang Shi Vincent Damian Hong T. Nguyen Miles E. Matsen Gregory J. Morton Joshua P. Thaler |
| author_sort | Mauricio D. Dorfman |
| collection | DOAJ |
| description | Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-induced obesity. |
| first_indexed | 2024-12-20T16:35:12Z |
| format | Article |
| id | doaj.art-c3d9bcc58c004e1b9f6eb255e257f3c4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:35:12Z |
| publishDate | 2017-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c3d9bcc58c004e1b9f6eb255e257f3c42022-12-21T19:33:10ZengNature PortfolioNature Communications2041-17232017-02-018111110.1038/ncomms14556Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in miceMauricio D. Dorfman0Jordan E. Krull1John D. Douglass2Rachael Fasnacht3Fernando Lara-Lince4Thomas H. Meek5Xiaogang Shi6Vincent Damian7Hong T. Nguyen8Miles E. Matsen9Gregory J. Morton10Joshua P. Thaler11UW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUW Diabetes Institute and Department of Medicine, University of WashingtonUnlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-induced obesity.https://doi.org/10.1038/ncomms14556 |
| spellingShingle | Mauricio D. Dorfman Jordan E. Krull John D. Douglass Rachael Fasnacht Fernando Lara-Lince Thomas H. Meek Xiaogang Shi Vincent Damian Hong T. Nguyen Miles E. Matsen Gregory J. Morton Joshua P. Thaler Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice Nature Communications |
| title | Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice |
| title_full | Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice |
| title_fullStr | Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice |
| title_full_unstemmed | Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice |
| title_short | Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice |
| title_sort | sex differences in microglial cx3cr1 signalling determine obesity susceptibility in mice |
| url | https://doi.org/10.1038/ncomms14556 |
| work_keys_str_mv | AT mauricioddorfman sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT jordanekrull sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT johnddouglass sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT rachaelfasnacht sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT fernandolaralince sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT thomashmeek sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT xiaogangshi sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT vincentdamian sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT hongtnguyen sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT milesematsen sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT gregoryjmorton sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice AT joshuapthaler sexdifferencesinmicroglialcx3cr1signallingdetermineobesitysusceptibilityinmice |