Fibrotic scar after experimental autoimmune encephalomyelitis inhibits oligodendrocyte differentiation

Fibrotic scar after experimental autoimmune encephalomyelitis inhibits oligodendrocyte differentiation

Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity of oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes is likely influenced by many aspects of the lesion environ...

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Bibliographic Details
Main Authors: Stephanie L. Yahn, Jiajun Li, Irene Goo, Han Gao, Roberta Brambilla, Jae K. Lee
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Subjects:
Fibrosis
EAE
MS
Myelination
Fibrotic scar
Perivascular fibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303493

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