Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment
The ultimate goal of the treatment of schizophrenia is recovery, a notion related to improvement of cognitive and social functioning. Cognitive remediation therapies (CRT), one of the most effective cognition enhancing methods, have been shown to moderately improve social functioning. For this purpo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00178/full |
| _version_ | 1818231412600340480 |
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| author | Kazuyoshi Takeda Tomiki Sumiyoshi Madoka Matsumoto Kou Murayama Kou Murayama Satoru Ikezawa Kenji Matsumoto Kazuyuki Nakagome |
| author_facet | Kazuyoshi Takeda Tomiki Sumiyoshi Madoka Matsumoto Kou Murayama Kou Murayama Satoru Ikezawa Kenji Matsumoto Kazuyuki Nakagome |
| author_sort | Kazuyoshi Takeda |
| collection | DOAJ |
| description | The ultimate goal of the treatment of schizophrenia is recovery, a notion related to improvement of cognitive and social functioning. Cognitive remediation therapies (CRT), one of the most effective cognition enhancing methods, have been shown to moderately improve social functioning. For this purpose, intrinsic motivation, related to internal values such as interest and enjoyment, has been shown to play a key role. Although the impairment of intrinsic motivation is one of the characteristics of schizophrenia, its neural mechanisms remain unclear. This is related to the lack of feasible measures of intrinsic motivation, and its response to treatment. According to the self-determination theory (SDT), not only intrinsic motivation, but extrinsic motivation has been reported to enhance learning and memory in healthy subjects to some extent. This finding suggests the contribution of different types of motivation to potentiate the ability of the CRT to treat cognitive impairment of schizophrenia. In this paper, we provide a review of psychological characteristics, assessment methods, and neural correlates of intrinsic motivation in healthy subjects and patients with schizophrenia. Particularly, we focus on neuroimaging studies of intrinsic motivation, including our own. These considerations are relevant to enhancement of functional outcomes of schizophrenia. |
| first_indexed | 2024-12-12T10:49:59Z |
| format | Article |
| id | doaj.art-c3dd0a50f2454a18b289f0e8e8f3145b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T10:49:59Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-c3dd0a50f2454a18b289f0e8e8f3145b2022-12-22T00:26:48ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-06-01910.3389/fpsyt.2018.00178348143Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive ImpairmentKazuyoshi Takeda0Tomiki Sumiyoshi1Madoka Matsumoto2Kou Murayama3Kou Murayama4Satoru Ikezawa5Kenji Matsumoto6Kazuyuki Nakagome7Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Neuropsychiatry, The University of Tokyo Hospital, Tokyo, JapanSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, United KingdomResearch Institute, Kochi University of Technology, Kochi, JapanDepartment of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JapanBrain Science Institute, Tamagawa University, Tokyo, JapanNational Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanThe ultimate goal of the treatment of schizophrenia is recovery, a notion related to improvement of cognitive and social functioning. Cognitive remediation therapies (CRT), one of the most effective cognition enhancing methods, have been shown to moderately improve social functioning. For this purpose, intrinsic motivation, related to internal values such as interest and enjoyment, has been shown to play a key role. Although the impairment of intrinsic motivation is one of the characteristics of schizophrenia, its neural mechanisms remain unclear. This is related to the lack of feasible measures of intrinsic motivation, and its response to treatment. According to the self-determination theory (SDT), not only intrinsic motivation, but extrinsic motivation has been reported to enhance learning and memory in healthy subjects to some extent. This finding suggests the contribution of different types of motivation to potentiate the ability of the CRT to treat cognitive impairment of schizophrenia. In this paper, we provide a review of psychological characteristics, assessment methods, and neural correlates of intrinsic motivation in healthy subjects and patients with schizophrenia. Particularly, we focus on neuroimaging studies of intrinsic motivation, including our own. These considerations are relevant to enhancement of functional outcomes of schizophrenia.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00178/fullintrinsic motivationcognitive remediation therapyschizophrenialateral prefrontal cortexstriatumself-determination theory |
| spellingShingle | Kazuyoshi Takeda Tomiki Sumiyoshi Madoka Matsumoto Kou Murayama Kou Murayama Satoru Ikezawa Kenji Matsumoto Kazuyuki Nakagome Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment Frontiers in Psychiatry intrinsic motivation cognitive remediation therapy schizophrenia lateral prefrontal cortex striatum self-determination theory |
| title | Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment |
| title_full | Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment |
| title_fullStr | Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment |
| title_full_unstemmed | Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment |
| title_short | Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment |
| title_sort | neural correlates for intrinsic motivational deficits of schizophrenia implications for therapeutics of cognitive impairment |
| topic | intrinsic motivation cognitive remediation therapy schizophrenia lateral prefrontal cortex striatum self-determination theory |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00178/full |
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