Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol
Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification method...
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| Format: | Article |
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MDPI AG
2020-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/2/108 |
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| author | Christofori M. R. R. Nastiti Thellie Ponto Yousuf Mohammed Michael S. Roberts Heather A. E. Benson |
| author_facet | Christofori M. R. R. Nastiti Thellie Ponto Yousuf Mohammed Michael S. Roberts Heather A. E. Benson |
| author_sort | Christofori M. R. R. Nastiti |
| collection | DOAJ |
| description | Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification method, and characterized and evaluated for their capabilities to penetrate/permeate the skin. In nanoformulations, the thermodynamic activity of the RSV penetration into/permeation through the skin was correlated with the thermodynamic activity of the RSV in the formulations. When terpenes were incorporated into the nanoformulations, the permeation of RSV through the skin increased and correlated with an increasing lipophilicity of the terpene. The nanoemulsion containing eugenol showed the highest RSV penetration into the stratum corneum (SC) and the epidermis-dermis-follicle region, whereas the limonene containing nanoemulsion had the highest RSV permeation through the skin (the enhancement ratios, compared to a saturated solution of RSV, were (i) 9.55 and (ii) 12.61, respectively, based on the average RSV amount (i) in each skin region and (ii) permeation through skin). |
| first_indexed | 2024-04-11T13:41:09Z |
| format | Article |
| id | doaj.art-c3dee17ced134169816f59b019eb7c21 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T13:41:09Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj.art-c3dee17ced134169816f59b019eb7c212022-12-22T04:21:16ZengMDPI AGPharmaceutics1999-49232020-01-0112210810.3390/pharmaceutics12020108pharmaceutics12020108Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant ResveratrolChristofori M. R. R. Nastiti0Thellie Ponto1Yousuf Mohammed2Michael S. Roberts3Heather A. E. Benson4School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6845, AustraliaSchool of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6845, AustraliaTherapeutics Research Centre, Faculty of Medicine, The University of Queensland Diamantina Institute, Woolloongabba 4102, AustraliaTherapeutics Research Centre, Faculty of Medicine, The University of Queensland Diamantina Institute, Woolloongabba 4102, AustraliaSchool of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6845, AustraliaResveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification method, and characterized and evaluated for their capabilities to penetrate/permeate the skin. In nanoformulations, the thermodynamic activity of the RSV penetration into/permeation through the skin was correlated with the thermodynamic activity of the RSV in the formulations. When terpenes were incorporated into the nanoformulations, the permeation of RSV through the skin increased and correlated with an increasing lipophilicity of the terpene. The nanoemulsion containing eugenol showed the highest RSV penetration into the stratum corneum (SC) and the epidermis-dermis-follicle region, whereas the limonene containing nanoemulsion had the highest RSV permeation through the skin (the enhancement ratios, compared to a saturated solution of RSV, were (i) 9.55 and (ii) 12.61, respectively, based on the average RSV amount (i) in each skin region and (ii) permeation through skin).https://www.mdpi.com/1999-4923/12/2/108nanocarrierstargeted deliveryskin permeationresveratrolantioxidant |
| spellingShingle | Christofori M. R. R. Nastiti Thellie Ponto Yousuf Mohammed Michael S. Roberts Heather A. E. Benson Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol Pharmaceutics nanocarriers targeted delivery skin permeation resveratrol antioxidant |
| title | Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol |
| title_full | Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol |
| title_fullStr | Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol |
| title_full_unstemmed | Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol |
| title_short | Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol |
| title_sort | novel nanocarriers for targeted topical skin delivery of the antioxidant resveratrol |
| topic | nanocarriers targeted delivery skin permeation resveratrol antioxidant |
| url | https://www.mdpi.com/1999-4923/12/2/108 |
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