Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
The selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within short times and provide facile access to peptide macr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-08010-2 |
| _version_ | 1818978131650805760 |
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| author | Qunfeng Luo Youqi Tao Wangjian Sheng Jingxia Lu Huan Wang |
| author_facet | Qunfeng Luo Youqi Tao Wangjian Sheng Jingxia Lu Huan Wang |
| author_sort | Qunfeng Luo |
| collection | DOAJ |
| description | The selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within short times and provide facile access to peptide macrocycles. |
| first_indexed | 2024-12-20T16:38:46Z |
| format | Article |
| id | doaj.art-c3df2b6ef44148c49531f577004f9225 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:38:46Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c3df2b6ef44148c49531f577004f92252022-12-21T19:33:06ZengNature PortfolioNature Communications2041-17232019-01-011011910.1038/s41467-018-08010-2Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclizationQunfeng Luo0Youqi Tao1Wangjian Sheng2Jingxia Lu3Huan Wang4State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing UniversityThe selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within short times and provide facile access to peptide macrocycles.https://doi.org/10.1038/s41467-018-08010-2 |
| spellingShingle | Qunfeng Luo Youqi Tao Wangjian Sheng Jingxia Lu Huan Wang Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization Nature Communications |
| title | Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization |
| title_full | Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization |
| title_fullStr | Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization |
| title_full_unstemmed | Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization |
| title_short | Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization |
| title_sort | dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization |
| url | https://doi.org/10.1038/s41467-018-08010-2 |
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