Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion

Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion

Tuberous sclerosis complex (TSC) is caused by mutations in the hamartin (<i>TSC1</i>) or tuberin (<i>TSC2</i>) genes. Using a mouse model of TSC renal cystogenesis that we have previously described, the current studies delineate the metabolic changes in the kidney and their r...

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Bibliographic Details
Main Authors: Kamyar Zahedi, Sharon Barone, Marybeth Brooks, Tracy Murray Stewart, Robert A. Casero, Manoocher Soleimani
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
tuberous sclerosis complex
hamartin
kidney
principal cell
cystogenesis
metabolome and transcriptome
Online Access:https://www.mdpi.com/1422-0067/23/18/10601

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