LfcinB-Derived Peptides: Specific and punctual change of an amino acid in monomeric and dimeric sequences increase selective cytotoxicity in colon cancer cell lines

LfcinB-Derived Peptides: Specific and punctual change of an amino acid in monomeric and dimeric sequences increase selective cytotoxicity in colon cancer cell lines

We observed how a change of specific residues in LfcinB dimeric and palindromic sequences caused a notable increase in the cytotoxic activity against CaCo-2 cells while maintaining or even diminishing the level of the cytotoxic effect against normal fibroblast and HEK-293 cells. In both cases, the I...

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Bibliographic Details
Main Authors: Andrea Carolina Barragán-Cárdenas, Diego Sebastián Insuasty-Cepeda, Karen Johanna Cárdenas-Martínez, Joel López-Meza, Alejandra Ochoa-Zarzosa, Adriana Umaña-Pérez, Zuly Jenny Rivera-Monroy, Javier Eduardo García-Castañeda
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Arabian Journal of Chemistry
Subjects:
Bovine Lactoferricin
Colon cancer
Enhanced cytotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222003148

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