Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adults
Abstract Background Lipoprotein (a) [Lp(a)] is an apoB100-containing lipoprotein with high levels being positively associated with atherosclerotic cardiovascular disease. Lp(a) levels are genetically determined. However, previous studies report a negative association between Lp(a) and saturated fatt...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01884-2 |
| _version_ | 1797556808110309376 |
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| author | Anastasiya Matveyenko Heather Seid Kyungyeon Kim Rajasekhar Ramakrishnan Tiffany Thomas Nelsa Matienzo Gissette Reyes-Soffer |
| author_facet | Anastasiya Matveyenko Heather Seid Kyungyeon Kim Rajasekhar Ramakrishnan Tiffany Thomas Nelsa Matienzo Gissette Reyes-Soffer |
| author_sort | Anastasiya Matveyenko |
| collection | DOAJ |
| description | Abstract Background Lipoprotein (a) [Lp(a)] is an apoB100-containing lipoprotein with high levels being positively associated with atherosclerotic cardiovascular disease. Lp(a) levels are genetically determined. However, previous studies report a negative association between Lp(a) and saturated fatty acid intake. Currently, apoB100 lowering therapies are used to lower Lp(a) levels, and apheresis therapy is FDA approved for patients with extreme elevations of Lp(a). The current study analyzed the association of free-living diet components with plasma Lp(a) levels. Methods Dietary composition data was collected during screening visits for enrollment in previously completed lipid and lipoprotein metabolism studies at Columbia University Irving Medical Center via a standardized protocol by registered dietitians using 24 hour recalls. Data were analyzed with the Nutrition Data System for Research (Version 2018). Diet quality was calculated using the Healthy Eating Index (HEI) score. Fasting plasma Lp(a) levels were measured via an isoform-independent ELISA and apo(a) isoforms were measured using gel electrophoresis. Results We enrolled 28 subjects [Black (n = 18); Hispanic (n = 7); White (n = 3)]. The mean age was 48.3 ± 12.5 years with 17 males. Median level of Lp(a) was 79.9 nmol/L (34.4–146.0) and it was negatively associated with absolute (grams/day) and relative (percent of total calories) intake of dietary saturated fatty acids (SFA) (R = -0.43, P = 0.02, SFA …(% CAL): R = -0.38, P = 0.04), palmitic acid intake (R = -0.38, P = 0.05), and stearic acid intake (R = -0.40, P = 0.03). Analyses of associations with HEI score when stratified based on Lp(a) levels > or ≤ 100 nmol/L revealed no significant associations with any of the constituent factors. Conclusions Using 24 hour recall, we confirm previous findings that Lp(a) levels are negatively associated with dietary saturated fatty acid intake. Additionally, Lp(a) levels are not related to diet quality, as assessed by the HEI score. The mechanisms underlying the relationship of SFA with Lp(a) require further investigation. |
| first_indexed | 2024-03-10T17:08:12Z |
| format | Article |
| id | doaj.art-c3e603ddcd6e40eda8030fea2eef3f54 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-10T17:08:12Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-c3e603ddcd6e40eda8030fea2eef3f542023-11-20T10:45:31ZengBMCLipids in Health and Disease1476-511X2023-09-0122111010.1186/s12944-023-01884-2Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adultsAnastasiya Matveyenko0Heather Seid1Kyungyeon Kim2Rajasekhar Ramakrishnan3Tiffany Thomas4Nelsa Matienzo5Gissette Reyes-Soffer6Department of Medicine, Columbia University Vagelos College of Physicians and SurgeonsIrving Institute for Clinical and Translational Research, Columbia UniversityInstitute of Human Nutrition, Columbia UniversityCenter for Biomathematics, Department of Pediatrics, Columbia University Vagelos College of Physicians and SurgeonsDepartment of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and SurgeonsDepartment of Medicine, Columbia University Vagelos College of Physicians and SurgeonsDepartment of Medicine, Columbia University Vagelos College of Physicians and SurgeonsAbstract Background Lipoprotein (a) [Lp(a)] is an apoB100-containing lipoprotein with high levels being positively associated with atherosclerotic cardiovascular disease. Lp(a) levels are genetically determined. However, previous studies report a negative association between Lp(a) and saturated fatty acid intake. Currently, apoB100 lowering therapies are used to lower Lp(a) levels, and apheresis therapy is FDA approved for patients with extreme elevations of Lp(a). The current study analyzed the association of free-living diet components with plasma Lp(a) levels. Methods Dietary composition data was collected during screening visits for enrollment in previously completed lipid and lipoprotein metabolism studies at Columbia University Irving Medical Center via a standardized protocol by registered dietitians using 24 hour recalls. Data were analyzed with the Nutrition Data System for Research (Version 2018). Diet quality was calculated using the Healthy Eating Index (HEI) score. Fasting plasma Lp(a) levels were measured via an isoform-independent ELISA and apo(a) isoforms were measured using gel electrophoresis. Results We enrolled 28 subjects [Black (n = 18); Hispanic (n = 7); White (n = 3)]. The mean age was 48.3 ± 12.5 years with 17 males. Median level of Lp(a) was 79.9 nmol/L (34.4–146.0) and it was negatively associated with absolute (grams/day) and relative (percent of total calories) intake of dietary saturated fatty acids (SFA) (R = -0.43, P = 0.02, SFA …(% CAL): R = -0.38, P = 0.04), palmitic acid intake (R = -0.38, P = 0.05), and stearic acid intake (R = -0.40, P = 0.03). Analyses of associations with HEI score when stratified based on Lp(a) levels > or ≤ 100 nmol/L revealed no significant associations with any of the constituent factors. Conclusions Using 24 hour recall, we confirm previous findings that Lp(a) levels are negatively associated with dietary saturated fatty acid intake. Additionally, Lp(a) levels are not related to diet quality, as assessed by the HEI score. The mechanisms underlying the relationship of SFA with Lp(a) require further investigation.https://doi.org/10.1186/s12944-023-01884-2Lipoprotein(a)Diet qualityDietary componentsSaturated fatty acidsHEI |
| spellingShingle | Anastasiya Matveyenko Heather Seid Kyungyeon Kim Rajasekhar Ramakrishnan Tiffany Thomas Nelsa Matienzo Gissette Reyes-Soffer Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adults Lipids in Health and Disease Lipoprotein(a) Diet quality Dietary components Saturated fatty acids HEI |
| title | Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adults |
| title_full | Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adults |
| title_fullStr | Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adults |
| title_full_unstemmed | Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adults |
| title_short | Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adults |
| title_sort | association of free living diet composition with plasma lipoprotein a levels in healthy adults |
| topic | Lipoprotein(a) Diet quality Dietary components Saturated fatty acids HEI |
| url | https://doi.org/10.1186/s12944-023-01884-2 |
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