Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy

Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy

Phospholamban (<i>PLN</i>) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation, and it has been linked to arrhythmogenesis and early deat...

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Bibliographic Details
Main Authors: Mohit Kumar, Kobra Haghighi, Sheryl Koch, Jack Rubinstein, Francesca Stillitano, Roger J. Hajjar, Evangelia G. Kranias, Sakthivel Sadayappan
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
R14del-phospholamban
myofilaments
contractility
omecamtiv mecarbil
males
females
Online Access:https://www.mdpi.com/1422-0067/24/3/2675

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