3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels
Cellular models are needed to study disease in vitro and to screen drugs for toxicity and efficacy. Here the authors develop a bioprinting approach to transfer spheroids into self-healing support hydrogels at high resolution, which enables their patterning and fusion into high-cell density microtiss...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21029-2 |
| _version_ | 1818429288622325760 |
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| author | Andrew C. Daly Matthew D. Davidson Jason A. Burdick |
| author_facet | Andrew C. Daly Matthew D. Davidson Jason A. Burdick |
| author_sort | Andrew C. Daly |
| collection | DOAJ |
| description | Cellular models are needed to study disease in vitro and to screen drugs for toxicity and efficacy. Here the authors develop a bioprinting approach to transfer spheroids into self-healing support hydrogels at high resolution, which enables their patterning and fusion into high-cell density microtissues of prescribed spatial organization. |
| first_indexed | 2024-12-14T15:15:08Z |
| format | Article |
| id | doaj.art-c3e8be08fce540e59149aea73ed06887 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:15:08Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c3e8be08fce540e59149aea73ed068872022-12-21T22:56:24ZengNature PortfolioNature Communications2041-17232021-02-0112111310.1038/s41467-021-21029-23D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogelsAndrew C. Daly0Matthew D. Davidson1Jason A. Burdick2Department of Bioengineering, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaCellular models are needed to study disease in vitro and to screen drugs for toxicity and efficacy. Here the authors develop a bioprinting approach to transfer spheroids into self-healing support hydrogels at high resolution, which enables their patterning and fusion into high-cell density microtissues of prescribed spatial organization.https://doi.org/10.1038/s41467-021-21029-2 |
| spellingShingle | Andrew C. Daly Matthew D. Davidson Jason A. Burdick 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels Nature Communications |
| title | 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels |
| title_full | 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels |
| title_fullStr | 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels |
| title_full_unstemmed | 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels |
| title_short | 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels |
| title_sort | 3d bioprinting of high cell density heterogeneous tissue models through spheroid fusion within self healing hydrogels |
| url | https://doi.org/10.1038/s41467-021-21029-2 |
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