Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid Carcinoma
Objective To investigate the expression and clinical significance of S100A14 and LOXL2 in papillary thyroid carcinoma tissues. Methods Paraffin blocks from 90 cases of thyroid lesion were collected to make tissue microarray. The expression of S100A14 and LOXL2 in 30 cases of nodular goiter (NG), 30...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2021-06-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2021.20.1500.htm |
| _version_ | 1818740536651022336 |
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| author | WANG Donghai REN Li LI Teng ZHENG Jichun ZHU Jianping |
| author_facet | WANG Donghai REN Li LI Teng ZHENG Jichun ZHU Jianping |
| author_sort | WANG Donghai |
| collection | DOAJ |
| description | Objective To investigate the expression and clinical significance of S100A14 and LOXL2 in papillary thyroid carcinoma tissues. Methods Paraffin blocks from 90 cases of thyroid lesion were collected to make tissue microarray. The expression of S100A14 and LOXL2 in 30 cases of nodular goiter (NG), 30 cases of classic papillary thyroid carcinoma (CPTC) and 30 cases of high invasion papillary thyroid carcinoma were detected by immunohistochemistry. The correlation of S100A14 and LOXL2 expression with the clinicopathological characteristics of papillary thyroid carcinoma patients was investigated. Results S100A4 and LOXL2 were highly expressed in papillary thyroid carcinoma. There was a gradually increasing trend from the expression in NG group, CPTC group to high invasive group. The positive rate of S100A14 in papillary thyroid carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.05). There was significant difference of S100A14 and LOXL2 expression between CPTC group and high invasion group (P < 0.05). S100A14 expression was positively correlated with LOXL2 expression (r=0.332). Conclusion The high expression of S100A14 and LOXL2 may be related to the malignant biological behavior and invasiveness of papillary thyroid carcinoma, and S100A14 may promote lymph node metastasis. |
| first_indexed | 2024-12-18T01:42:17Z |
| format | Article |
| id | doaj.art-c3e92bd7d3b7443fa55cce01a0b2a665 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-18T01:42:17Z |
| publishDate | 2021-06-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-c3e92bd7d3b7443fa55cce01a0b2a6652022-12-21T21:25:17ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782021-06-0148659459910.3971/j.issn.1000-8578.2021.20.15008578.2021.20.1500Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid CarcinomaWANG Donghai0REN Li1LI Teng2ZHENG Jichun3ZHU Jianping4Department of Pathology, Air Force Medical Center of PLA, Beijing 100142, ChinaDepartment of Pathology, Air Force Medical Center of PLA, Beijing 100142, ChinaDepartment of Pathology, Air Force Medical Center of PLA, Beijing 100142, ChinaDepartment of Pathology, Air Force Medical Center of PLA, Beijing 100142, ChinaDepartment of Pathology, Air Force Medical Center of PLA, Beijing 100142, ChinaObjective To investigate the expression and clinical significance of S100A14 and LOXL2 in papillary thyroid carcinoma tissues. Methods Paraffin blocks from 90 cases of thyroid lesion were collected to make tissue microarray. The expression of S100A14 and LOXL2 in 30 cases of nodular goiter (NG), 30 cases of classic papillary thyroid carcinoma (CPTC) and 30 cases of high invasion papillary thyroid carcinoma were detected by immunohistochemistry. The correlation of S100A14 and LOXL2 expression with the clinicopathological characteristics of papillary thyroid carcinoma patients was investigated. Results S100A4 and LOXL2 were highly expressed in papillary thyroid carcinoma. There was a gradually increasing trend from the expression in NG group, CPTC group to high invasive group. The positive rate of S100A14 in papillary thyroid carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.05). There was significant difference of S100A14 and LOXL2 expression between CPTC group and high invasion group (P < 0.05). S100A14 expression was positively correlated with LOXL2 expression (r=0.332). Conclusion The high expression of S100A14 and LOXL2 may be related to the malignant biological behavior and invasiveness of papillary thyroid carcinoma, and S100A14 may promote lymph node metastasis.http://html.rhhz.net/ZLFZYJ/html/8578.2021.20.1500.htms100a14loxl2papillary thyroid carcinomapathologic variant |
| spellingShingle | WANG Donghai REN Li LI Teng ZHENG Jichun ZHU Jianping Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid Carcinoma Zhongliu Fangzhi Yanjiu s100a14 loxl2 papillary thyroid carcinoma pathologic variant |
| title | Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid Carcinoma |
| title_full | Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid Carcinoma |
| title_fullStr | Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid Carcinoma |
| title_full_unstemmed | Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid Carcinoma |
| title_short | Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid Carcinoma |
| title_sort | expression and clinical significance of s100a14 and loxl2 in papillary thyroid carcinoma |
| topic | s100a14 loxl2 papillary thyroid carcinoma pathologic variant |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2021.20.1500.htm |
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