5-Aminolevulinic Acid Attenuates Glucose-Regulated Protein 78 Expression and Hepatocyte Lipoapoptosis via Heme Oxygenase-1 Induction

5-Aminolevulinic Acid Attenuates Glucose-Regulated Protein 78 Expression and Hepatocyte Lipoapoptosis via Heme Oxygenase-1 Induction

Endoplasmic reticulum (ER) stress plays a pivotal role in the progression of steatohepatitis. 5-aminolevulinic acid (5-ALA), a precursor in the heme biosynthetic pathway, has recently been reported to induce heme oxygenase (HO)-1. HO-1 exerts important cytoprotective actions. In this study, we aimed...

Full description

Bibliographic Details
Main Authors: Takaaki Hashimoto, Takaaki Sugihara, Tsutomu Kanda, Tomoaki Takata, Hajime Isomoto
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
endoplasmic reticulum stress
heme oxygenase-1
glucose-regulated protein 78
steatohepatitis
5-aminolevulinic acid
Online Access:https://www.mdpi.com/1422-0067/22/21/11405

Similar Items

Similar Items