Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants
The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1936 |
| _version_ | 1797506469991546880 |
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| author | Katja Andrina Kravanja Matjaž Finšgar |
| author_facet | Katja Andrina Kravanja Matjaž Finšgar |
| author_sort | Katja Andrina Kravanja |
| collection | DOAJ |
| description | The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings. |
| first_indexed | 2024-03-10T04:34:03Z |
| format | Article |
| id | doaj.art-c3ec777f0b43434196f9a51ba34a874b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:34:03Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c3ec777f0b43434196f9a51ba34a874b2023-11-23T03:57:50ZengMDPI AGBiomedicines2227-90592021-12-01912193610.3390/biomedicines9121936Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic ImplantsKatja Andrina Kravanja0Matjaž Finšgar1Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, SloveniaFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, SloveniaThe development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings.https://www.mdpi.com/2227-9059/9/12/1936bioactive coatingsorthopedic implantscharacterization techniquescontrolled drug release |
| spellingShingle | Katja Andrina Kravanja Matjaž Finšgar Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants Biomedicines bioactive coatings orthopedic implants characterization techniques controlled drug release |
| title | Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants |
| title_full | Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants |
| title_fullStr | Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants |
| title_full_unstemmed | Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants |
| title_short | Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants |
| title_sort | analytical techniques for the characterization of bioactive coatings for orthopaedic implants |
| topic | bioactive coatings orthopedic implants characterization techniques controlled drug release |
| url | https://www.mdpi.com/2227-9059/9/12/1936 |
| work_keys_str_mv | AT katjaandrinakravanja analyticaltechniquesforthecharacterizationofbioactivecoatingsfororthopaedicimplants AT matjazfinsgar analyticaltechniquesforthecharacterizationofbioactivecoatingsfororthopaedicimplants |