Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis
ObjectiveBreast cancer is one of the most common causes of death among women. Statins, typically used for cholesterol management, have been hypothesized to reduce recurrence and mortality rates in breast cancer. However, this association remains a subject of debate. This study evaluates the potentia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1256747/full |
| _version_ | 1797387693289635840 |
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| author | Xiaolin Jia Ye Lu Zili Xu Qingqing Mu |
| author_facet | Xiaolin Jia Ye Lu Zili Xu Qingqing Mu |
| author_sort | Xiaolin Jia |
| collection | DOAJ |
| description | ObjectiveBreast cancer is one of the most common causes of death among women. Statins, typically used for cholesterol management, have been hypothesized to reduce recurrence and mortality rates in breast cancer. However, this association remains a subject of debate. This study evaluates the potential impact of statins on breast cancer recurrence and mortality.MethodsA comprehensive search was conducted in the PubMed, EMBASE, and Cochrane databases for articles published up to June 2023. These articles examined the effect of statins on breast cancer recurrence and mortality both before and after diagnosis. The analysis was performed using random-effects models, calculating pooled hazard ratios (HR) and their 95% confidence intervals (CI).ResultsA total of 31 cohort studies, involving 261,834 female breast cancer patients, were included in this analysis. It was found that statin use prior to diagnosis was associated with a decrease in overall mortality (HR, 0.8; 95% CI, 0.69–0.93; I2 = 77.6%; P = 0.001) and breast cancer-specific mortality (HR, 0.76; 95% CI, 0.67–0.87; I2 = 72.7%; P = 0.005). Additionally, statin use after diagnosis was observed to reduce the recurrence of breast cancer (HR, 0.71; 95% CI, 0.61–0.82; I2 = 60%; P = 0.003), overall mortality (HR, 0.81; 95% CI, 0.70–0.92; I2 = 80.7%; P < 0.001), and breast cancer-specific mortality (HR, 0.76; 95% CI, 0.67–0.86; I2 = 74.5%; P < 0.001).ConclusionsThe findings of this study indicate that statin usage, both before and after breast cancer diagnosis, may be associated with reduced risks of overall and breast cancer-specific mortality, as well as lower recurrence rates. |
| first_indexed | 2024-03-08T22:29:44Z |
| format | Article |
| id | doaj.art-c3f507f3a66a4cdf98d9702e96221889 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T22:29:44Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c3f507f3a66a4cdf98d9702e962218892023-12-18T07:29:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-12-011310.3389/fonc.2023.12567471256747Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysisXiaolin Jia0Ye Lu1Zili Xu2Qingqing Mu3Department of Infectious Diseases, The Third People’s Hospital of Longgang Shenzhen, Shenzhen, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaClinical Medicine School of Zhengzhou University, Zhengzhou, ChinaClinical Medicine School of Zhengzhou University, Zhengzhou, ChinaObjectiveBreast cancer is one of the most common causes of death among women. Statins, typically used for cholesterol management, have been hypothesized to reduce recurrence and mortality rates in breast cancer. However, this association remains a subject of debate. This study evaluates the potential impact of statins on breast cancer recurrence and mortality.MethodsA comprehensive search was conducted in the PubMed, EMBASE, and Cochrane databases for articles published up to June 2023. These articles examined the effect of statins on breast cancer recurrence and mortality both before and after diagnosis. The analysis was performed using random-effects models, calculating pooled hazard ratios (HR) and their 95% confidence intervals (CI).ResultsA total of 31 cohort studies, involving 261,834 female breast cancer patients, were included in this analysis. It was found that statin use prior to diagnosis was associated with a decrease in overall mortality (HR, 0.8; 95% CI, 0.69–0.93; I2 = 77.6%; P = 0.001) and breast cancer-specific mortality (HR, 0.76; 95% CI, 0.67–0.87; I2 = 72.7%; P = 0.005). Additionally, statin use after diagnosis was observed to reduce the recurrence of breast cancer (HR, 0.71; 95% CI, 0.61–0.82; I2 = 60%; P = 0.003), overall mortality (HR, 0.81; 95% CI, 0.70–0.92; I2 = 80.7%; P < 0.001), and breast cancer-specific mortality (HR, 0.76; 95% CI, 0.67–0.86; I2 = 74.5%; P < 0.001).ConclusionsThe findings of this study indicate that statin usage, both before and after breast cancer diagnosis, may be associated with reduced risks of overall and breast cancer-specific mortality, as well as lower recurrence rates.https://www.frontiersin.org/articles/10.3389/fonc.2023.1256747/fullstatinsbreast canceroverall mortalitydisease-induced mortalityrecurrence |
| spellingShingle | Xiaolin Jia Ye Lu Zili Xu Qingqing Mu Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis Frontiers in Oncology statins breast cancer overall mortality disease-induced mortality recurrence |
| title | Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis |
| title_full | Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis |
| title_fullStr | Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis |
| title_full_unstemmed | Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis |
| title_short | Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis |
| title_sort | impact of statin use on breast cancer recurrence and mortality before and after diagnosis a systematic review and meta analysis |
| topic | statins breast cancer overall mortality disease-induced mortality recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1256747/full |
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