Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk
Abstract Soy consumption has received considerable attention for its potential role in reducing cancer incidence and mortality. However, its effects on gastrointestinal (GI) cancer are controversial. Therefore, we performed a meta-analysis to evaluate the association between soy consumption and gast...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-03692-y |
| _version_ | 1818752239583363072 |
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| author | Demin Lu Chi Pan Chenyang Ye Huijie Duan Fei Xu Li Yin Wei Tian Suzhan Zhang |
| author_facet | Demin Lu Chi Pan Chenyang Ye Huijie Duan Fei Xu Li Yin Wei Tian Suzhan Zhang |
| author_sort | Demin Lu |
| collection | DOAJ |
| description | Abstract Soy consumption has received considerable attention for its potential role in reducing cancer incidence and mortality. However, its effects on gastrointestinal (GI) cancer are controversial. Therefore, we performed a meta-analysis to evaluate the association between soy consumption and gastrointestinal cancer risk by searching for prospective studies in PubMed, Web of Science, EMBASE and the reference lists of the included articles. The study-specific odds ratio (OR), relative risk (RR) or hazard ratio (HR) estimates and 95% confidence intervals (CIs) were pooled using either a fixed-effect or random-effect model. Twenty-two independent prospective studies were eligible for our meta-analysis, including 21 cohort studies and one nested case-control study. Soy product consumption was inversely associated with the incidence of overall GI cancer (0.857; 95% CI: 0.766, 0.959) and the gastric cancer subgroup (0.847; 95% CI: 0.722, 0.994) but not the colorectal cancer subgroup. After stratifying the results according to gender, an inverse association was observed between soy product intake and the incidence of GI cancer for females (0.711; 95% CI: 0.506, 0.999) but not for males. |
| first_indexed | 2024-12-18T04:48:18Z |
| format | Article |
| id | doaj.art-c3f614ed89884e1d91df6bb849e71b34 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:48:18Z |
| publishDate | 2017-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c3f614ed89884e1d91df6bb849e71b342022-12-21T21:20:30ZengNature PortfolioScientific Reports2045-23222017-06-017111410.1038/s41598-017-03692-yMeta-analysis of Soy Consumption and Gastrointestinal Cancer RiskDemin Lu0Chi Pan1Chenyang Ye2Huijie Duan3Fei Xu4Li Yin5Wei Tian6Suzhan Zhang7Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang UniversityCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang UniversityCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang UniversityCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang UniversityCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang UniversityCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang UniversityCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang UniversityCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract Soy consumption has received considerable attention for its potential role in reducing cancer incidence and mortality. However, its effects on gastrointestinal (GI) cancer are controversial. Therefore, we performed a meta-analysis to evaluate the association between soy consumption and gastrointestinal cancer risk by searching for prospective studies in PubMed, Web of Science, EMBASE and the reference lists of the included articles. The study-specific odds ratio (OR), relative risk (RR) or hazard ratio (HR) estimates and 95% confidence intervals (CIs) were pooled using either a fixed-effect or random-effect model. Twenty-two independent prospective studies were eligible for our meta-analysis, including 21 cohort studies and one nested case-control study. Soy product consumption was inversely associated with the incidence of overall GI cancer (0.857; 95% CI: 0.766, 0.959) and the gastric cancer subgroup (0.847; 95% CI: 0.722, 0.994) but not the colorectal cancer subgroup. After stratifying the results according to gender, an inverse association was observed between soy product intake and the incidence of GI cancer for females (0.711; 95% CI: 0.506, 0.999) but not for males.https://doi.org/10.1038/s41598-017-03692-y |
| spellingShingle | Demin Lu Chi Pan Chenyang Ye Huijie Duan Fei Xu Li Yin Wei Tian Suzhan Zhang Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk Scientific Reports |
| title | Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk |
| title_full | Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk |
| title_fullStr | Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk |
| title_full_unstemmed | Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk |
| title_short | Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk |
| title_sort | meta analysis of soy consumption and gastrointestinal cancer risk |
| url | https://doi.org/10.1038/s41598-017-03692-y |
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