COVID-19: molecular targets, drug repurposing and new avenues for drug discovery

COVID-19: molecular targets, drug repurposing and new avenues for drug discovery

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as...

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Bibliographic Details
Main Authors: Mario Roberto Senger, Tereza Cristina Santos Evangelista, Rafael Ferreira Dantas, Marcos Vinicius da Silva Santana, Luiz Carlos Saramago Gonçalves, Lauro Ribeiro de Souza Neto, Sabrina Baptista Ferreira, Floriano Paes Silva-Junior
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ)
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
COVID-19
SARS-CoV-2
drug repurposing
drug discovery
replication cycle
drug targets
Online Access:http://www.scielo.br/pdf/mioc/v115/1678-8060-mioc-115-e200254.pdf
Description
Summary:Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.
ISSN:1678-8060

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