Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27
Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gast...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/2/279 |
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| author | Gabriel Silva Felipe Teixeira Lima Viviane Seba Ana Laura Mendes Lourenço Thaise Graminha Lucas Bianca Vieira de Andrade Guilherme Silva Torrezan Carlos Roberto Polaquini Marcelo Engracia Garcia Lucélio Bernardes Couto Reinaldo Bulgarelli Bestetti Suzelei de Castro França Ana Lúcia Fachin Luis Octavio Regasini Mozart Marins |
| author_facet | Gabriel Silva Felipe Teixeira Lima Viviane Seba Ana Laura Mendes Lourenço Thaise Graminha Lucas Bianca Vieira de Andrade Guilherme Silva Torrezan Carlos Roberto Polaquini Marcelo Engracia Garcia Lucélio Bernardes Couto Reinaldo Bulgarelli Bestetti Suzelei de Castro França Ana Lúcia Fachin Luis Octavio Regasini Mozart Marins |
| author_sort | Gabriel Silva |
| collection | DOAJ |
| description | Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy. |
| first_indexed | 2024-12-11T21:13:42Z |
| format | Article |
| id | doaj.art-c3f939da83a84967918f7b5289fbe960 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T21:13:42Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c3f939da83a84967918f7b5289fbe9602022-12-22T00:50:39ZengMDPI AGMolecules1420-30492018-01-0123227910.3390/molecules23020279molecules23020279Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27Gabriel Silva0Felipe Teixeira Lima1Viviane Seba2Ana Laura Mendes Lourenço3Thaise Graminha Lucas4Bianca Vieira de Andrade5Guilherme Silva Torrezan6Carlos Roberto Polaquini7Marcelo Engracia Garcia8Lucélio Bernardes Couto9Reinaldo Bulgarelli Bestetti10Suzelei de Castro França11Ana Lúcia Fachin12Luis Octavio Regasini13Mozart Marins14Biotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilBiotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilBiotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilBiotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilBiotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilBiotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilLaboratory of Green and Medicinal Chemistry, Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, SP CEP 15054-000, BrazilLaboratory of Green and Medicinal Chemistry, Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, SP CEP 15054-000, BrazilMedicine School, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilMedicine School, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilMedicine School, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilBiotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilBiotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilLaboratory of Green and Medicinal Chemistry, Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, SP CEP 15054-000, BrazilBiotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, BrazilGastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.http://www.mdpi.com/1420-3049/23/2/279gastric cancercurcuminmatrix metalloproteinase 2migrationinvasionapoptosis |
| spellingShingle | Gabriel Silva Felipe Teixeira Lima Viviane Seba Ana Laura Mendes Lourenço Thaise Graminha Lucas Bianca Vieira de Andrade Guilherme Silva Torrezan Carlos Roberto Polaquini Marcelo Engracia Garcia Lucélio Bernardes Couto Reinaldo Bulgarelli Bestetti Suzelei de Castro França Ana Lúcia Fachin Luis Octavio Regasini Mozart Marins Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 Molecules gastric cancer curcumin matrix metalloproteinase 2 migration invasion apoptosis |
| title | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
| title_full | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
| title_fullStr | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
| title_full_unstemmed | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
| title_short | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
| title_sort | curcumin analog ch 5 suppresses the proliferation migration and invasion of the human gastric cancer cell line hgc 27 |
| topic | gastric cancer curcumin matrix metalloproteinase 2 migration invasion apoptosis |
| url | http://www.mdpi.com/1420-3049/23/2/279 |
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