Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege

Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege

Interleukin-27 is constitutively secreted by microglia in the retina or brain, and upregulation of IL-27 during neuroinflammation suppresses encephalomyelitis and autoimmune uveitis. However, while IL-35 is structurally and functionally similar to IL-27, the intrinsic roles of IL-35 in CNS tissues a...

Full description

Bibliographic Details
Main Authors:	Cheng-Rong Yu, Manoj Kumar Yadav, Minkyung Kang, Yingyos Jittayasothorn, Lijin Dong, Charles E. Egwuagu
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Series:	International Journal of Molecular Sciences
Subjects:	uveitis experimental autoimmune uveitis (EAU) interleukin 35 (IL-35) immunosuppressive cytokines Th1/Th17 cells photoreceptors
Online Access:	https://www.mdpi.com/1422-0067/23/15/8156

Similar Items

STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice
by: Evaristus C. Mbanefo, et al.
Published: (2021-09-01)

Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis
by: Minkyung Kang, et al.
Published: (2020-05-01)

Effect of interleukin (IL)-35 on IL-17 expression and production by human CD4+ T cells
by: Kosuke Okada, et al.
Published: (2017-02-01)

Research progress on effect of IL-17 in ocular diseases
by: Lan Wang, et al.
Published: (2021-08-01)

Expression of interleukin-35 and type 2 cytokines in children with acute allergic asthma
by: Zhangqiao Cai, et al.
Published: (2021-09-01)

Deletion of <i>Irf4</i> in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4<sup>+</sup> T Cell Differentiation and Metabolism
by: Minkyung Kang, et al.
Published: (2021-03-01)

High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis
by: Fleurieke H. Verhagen, et al.
Published: (2018-10-01)

Quantitative Assessment of Experimental Ocular Inflammatory Disease
by: Lydia J. Bradley, et al.
Published: (2021-06-01)

Increased Interleukin-35 suppresses peripheral CD14+ monocytes function in patients with Kawasaki disease
by: Haijian Xing, et al.
Published: (2020-04-01)

Tolerance Induction in Relation to the Eye
by: Igal Gery, et al.
Published: (2018-10-01)

Role of Cytokines in experimental and clinical uveitis</
by: Singh Vijay, et al.
Published: (2001-01-01)

Cytotoxic effect of specific T cells from mice with experimental autoimmune uveitis on murine photoreceptor cells
by: Zheng-Feng Liu, et al.
Published: (2020-08-01)

Case Report: Delayed Onset Multi-Organ Toxicities in a Melanoma Patient Achieving Complete Response to BRAF/MEK Inhibition
by: Hannah M. Knochelmann, et al.
Published: (2022-03-01)

Methotrexate Effectively Controls Ocular Inflammation in Japanese Patients With Non-infectious Uveitis
by: Yosuke Harada, et al.
Published: (2021-11-01)

Interleukin-35 in Iraqi's Menopausal Women with Osteoporosis
by: Husam S. Jasim
Published: (2017-03-01)

A Review of Systemic Biologics and Local Immunosuppressive Medications in Uveitis
by: Neesurg S. Mehta, et al.
Published: (2022-05-01)

Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis
by: Sheng-Min Lo, et al.
Published: (2022-01-01)

The Molecular Role of IL-35 in Non-Small Cell Lung Cancer
by: Yuqiu Hao, et al.
Published: (2022-05-01)

Current Landscape of Uveitis Specialists in the United States
by: Edmund Tsui, et al.
Published: (2022-07-01)

Biologic Agents in Inflammatory Eye Disease
by: Chiara Posarelli, et al.
Published: (2011-01-01)

Low-dose cyclosporine treatment for sight-threatening uveitis: Efficacy, toxicity, and tolerance
by: Mathews D, et al.
Published: (2010-01-01)

Immunosuppressive therapy in non-infections uveitis and retinovasculitis
by: E. A. Drozdova
Published: (2014-07-01)

Study on the effect of miR-223-3p regulating transcription factor Rbpj on the differentiation of Th1 and Th17 cells in rats with experimental autoimmune uveitis
by: Meng-Xian Zhou, et al.
Published: (2022-05-01)

Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells
by: Li-Fei Yuan, et al.
Published: (2015-08-01)

Current Research of the Roles of IL-35 in Tumor Progression
by: Chongbiao HUANG, et al.
Published: (2016-04-01)

Extrapulmonary sarcoidosis with a focus on cardiac, nervous system, and ocular involvement
by: John A. Belperio, et al.
Published: (2021-07-01)

Serum IL-35 and TGF-β1 expression levels in patients with acute anterior uveitis and their clinical significance
by: Ai-Fang Fan, et al.
Published: (2021-01-01)

KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis
by: Tian Niu, et al.
Published: (2019-12-01)

La uveítis, comportamiento clínico epidemiológico en Pinar del Río
by: Barbara Taysel Naranjo Valladares, et al.
Published: (2015-04-01)

The diagnostic value of interleukin 35 as a septic biomarker: A meta-analysis
by: Yuanhui Hu, et al.
Published: (2022-11-01)

Interleukin-35 on B cell and T cell induction and regulation
by: Ai Huang, et al.
Published: (2017-08-01)

<i>Casitas B-lineage lymphoma</i> Gene Mutation Ocular Phenotype
by: Christine Fardeau, et al.
Published: (2022-07-01)

Pattern of uveitis from a tertiary eye care center in Himalayan belt of North India
by: Sneha Pandurangan, et al.
Published: (2022-01-01)

Uveítis intermedia: Experiencias terapéuticas Intermediate uveitis: Therapeutic experiences
by: Sandra M. Borges Pérez, et al.
Published: (2001-12-01)

Experiencias terapéuticas en la uveítis intermedia Therapeutical experiences in intermediate uveitis
by: Sandra Borges Pérez, et al.
Published: (1999-12-01)

Lo mejor del año en uveítis 2017 Best of 2017 in uveitis
by: Clara Martínez-Rubio, et al.
Published: (2018-01-01)

PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2
by: Liu Z, et al.
Published: (2022-04-01)

Ocular sarcoidosis, to screen or not to screen?
by: Sanna Leinonen, et al.
Published: (2024-02-01)

Treatment in Latent Tuberculosis Uveitis—Is Immunosuppression Effective or Is Conventional 3- or 4-Drug Antituberculosis Therapy Mandatory?
by: Eileen Bigdon, et al.
Published: (2022-04-01)

Tuberculous uveitis presenting as pigmented hypopyon – A case report
by: Sachin B. Shetty, M.S., et al.
Published: (2017-09-01)