A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models

A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models

Alzheimer’s disease (AD) is a progressive neurological disorder with multifactorial and heterogeneous causes. AD involves several etiopathogenic mechanisms such as aberrant protein accumulation, neurotransmitter deficits, synaptic dysfunction and neuroinflammation, which lead to cognitive decline. U...

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Bibliographic Details
Main Authors: Júlia Jarne-Ferrer, Christian Griñán-Ferré, Aina Bellver-Sanchis, Santiago Vázquez, Diego Muñoz-Torrero, Mercè Pallàs
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceuticals
Subjects:
soluble epoxide hydrolase
acetylcholinesterase
cognitive decline
Alzheimer’s disease
neuroinflammation
multitarget agents
Online Access:https://www.mdpi.com/1424-8247/15/8/908

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