Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation
Oxidative stress in adipose tissue is a crucial pathogenic mechanism of obesity-associated cardiovascular diseases. Chronic low-grade inflammation caused by obesity increases ROS production and dysregulation of adipocytokines. Leonurine (LEO) is an active alkaloid extracted from Herba Leonuri and pl...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/7/1338 |
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| author | Xiao-Dong Shi Jia-Xin Zhang Xi-De Hu Tao Zhuang Ning Lu Cheng-Chao Ruan |
| author_facet | Xiao-Dong Shi Jia-Xin Zhang Xi-De Hu Tao Zhuang Ning Lu Cheng-Chao Ruan |
| author_sort | Xiao-Dong Shi |
| collection | DOAJ |
| description | Oxidative stress in adipose tissue is a crucial pathogenic mechanism of obesity-associated cardiovascular diseases. Chronic low-grade inflammation caused by obesity increases ROS production and dysregulation of adipocytokines. Leonurine (LEO) is an active alkaloid extracted from Herba Leonuri and plays a protective role in the cardiovascular system. The present study tested whether LEO alleviates inflammation and oxidative stress, and improves vascular function in an obese mouse model. Here, we found that obesity leads to inflammation and oxidative stress in epididymal white adipose tissue (EWAT), as well as vascular dysfunction. LEO significantly improved inflammation and oxidative stress both in vivo and in vitro. Obesity-induced vascular dysfunction was also improved by LEO as evidenced by the ameliorated vascular tone and decreased mesenteric artery fibrosis. Using mass spectrometry, we identified YTHDF1 as the direct target of LEO. Taken together, we demonstrated that LEO improves oxidative stress and vascular remodeling induced by obesity and targets YTHDF1, raising the possibility of LEO treating other obesity-related metabolic syndromes. |
| first_indexed | 2024-03-09T10:23:30Z |
| format | Article |
| id | doaj.art-c3fac70a8a154db499b00e87c3aa852e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T10:23:30Z |
| publishDate | 2022-07-01 |
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| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c3fac70a8a154db499b00e87c3aa852e2023-12-01T21:49:56ZengMDPI AGAntioxidants2076-39212022-07-01117133810.3390/antiox11071338Leonurine Attenuates Obesity-Related Vascular Dysfunction and InflammationXiao-Dong Shi0Jia-Xin Zhang1Xi-De Hu2Tao Zhuang3Ning Lu4Cheng-Chao Ruan5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, ChinaDepartment of Clinical Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, ChinaOxidative stress in adipose tissue is a crucial pathogenic mechanism of obesity-associated cardiovascular diseases. Chronic low-grade inflammation caused by obesity increases ROS production and dysregulation of adipocytokines. Leonurine (LEO) is an active alkaloid extracted from Herba Leonuri and plays a protective role in the cardiovascular system. The present study tested whether LEO alleviates inflammation and oxidative stress, and improves vascular function in an obese mouse model. Here, we found that obesity leads to inflammation and oxidative stress in epididymal white adipose tissue (EWAT), as well as vascular dysfunction. LEO significantly improved inflammation and oxidative stress both in vivo and in vitro. Obesity-induced vascular dysfunction was also improved by LEO as evidenced by the ameliorated vascular tone and decreased mesenteric artery fibrosis. Using mass spectrometry, we identified YTHDF1 as the direct target of LEO. Taken together, we demonstrated that LEO improves oxidative stress and vascular remodeling induced by obesity and targets YTHDF1, raising the possibility of LEO treating other obesity-related metabolic syndromes.https://www.mdpi.com/2076-3921/11/7/1338obesityvascular dysfunctioninflammationoxidative stressLEOYTHDF1 |
| spellingShingle | Xiao-Dong Shi Jia-Xin Zhang Xi-De Hu Tao Zhuang Ning Lu Cheng-Chao Ruan Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation Antioxidants obesity vascular dysfunction inflammation oxidative stress LEO YTHDF1 |
| title | Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation |
| title_full | Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation |
| title_fullStr | Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation |
| title_full_unstemmed | Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation |
| title_short | Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation |
| title_sort | leonurine attenuates obesity related vascular dysfunction and inflammation |
| topic | obesity vascular dysfunction inflammation oxidative stress LEO YTHDF1 |
| url | https://www.mdpi.com/2076-3921/11/7/1338 |
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