Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseases
Recent technological advance in single-cell and single-nucleus transcriptomics has made it possible to generate an unprecedentedly detailed landscape of neuro-immune interactions in healthy and diseased brains. In this review, we overview the recent literature that catalogs single-cell-level gene ex...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-07-01
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| Series: | Animal Cells and Systems |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2022.2110937 |
| _version_ | 1828121372179562496 |
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| author | Hyun Jung Park Hosung Jung |
| author_facet | Hyun Jung Park Hosung Jung |
| author_sort | Hyun Jung Park |
| collection | DOAJ |
| description | Recent technological advance in single-cell and single-nucleus transcriptomics has made it possible to generate an unprecedentedly detailed landscape of neuro-immune interactions in healthy and diseased brains. In this review, we overview the recent literature that catalogs single-cell-level gene expression in brains with signs of inflammation, focusing on maternal immune activation, viral infection, and auto-immune diseases. The literature also includes a series of papers that provide strong evidence for immunological contributions to neurodegenerative diseases, which, in a strict sense, are not considered neuroinflammatory. To help with the discussion, we present a diagram of experimental and analytical flows in the single-cell analysis of the brain. We also discuss the recurring themes of neuro-immune interactions and suggest future research directions. |
| first_indexed | 2024-04-11T14:19:26Z |
| format | Article |
| id | doaj.art-c3fdaf6c3dc248e0b452d43d7639f79c |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-04-11T14:19:26Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-c3fdaf6c3dc248e0b452d43d7639f79c2022-12-22T04:19:07ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852022-07-0126413714710.1080/19768354.2022.2110937Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseasesHyun Jung Park0Hosung Jung1Samsung Medical Center, Samsung Genome Institute, Seoul, Republic of KoreaDepartment of Anatomy, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of KoreaRecent technological advance in single-cell and single-nucleus transcriptomics has made it possible to generate an unprecedentedly detailed landscape of neuro-immune interactions in healthy and diseased brains. In this review, we overview the recent literature that catalogs single-cell-level gene expression in brains with signs of inflammation, focusing on maternal immune activation, viral infection, and auto-immune diseases. The literature also includes a series of papers that provide strong evidence for immunological contributions to neurodegenerative diseases, which, in a strict sense, are not considered neuroinflammatory. To help with the discussion, we present a diagram of experimental and analytical flows in the single-cell analysis of the brain. We also discuss the recurring themes of neuro-immune interactions and suggest future research directions.https://www.tandfonline.com/doi/10.1080/19768354.2022.2110937Single-cell RNA sequencingCOVID-19multiple sclerosisAlzheimer's diseaseParkinson's disease |
| spellingShingle | Hyun Jung Park Hosung Jung Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseases Animal Cells and Systems Single-cell RNA sequencing COVID-19 multiple sclerosis Alzheimer's disease Parkinson's disease |
| title | Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseases |
| title_full | Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseases |
| title_fullStr | Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseases |
| title_full_unstemmed | Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseases |
| title_short | Neuro-immune interactions at single-cell resolution in neurodevelopmental, infectious, and neurodegenerative diseases |
| title_sort | neuro immune interactions at single cell resolution in neurodevelopmental infectious and neurodegenerative diseases |
| topic | Single-cell RNA sequencing COVID-19 multiple sclerosis Alzheimer's disease Parkinson's disease |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2022.2110937 |
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