Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke
Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of AA has become a research hotspot. Furthermore,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1083972/full |
| _version_ | 1828039464177369088 |
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| author | Pan Huang |
| author_facet | Pan Huang |
| author_sort | Pan Huang |
| collection | DOAJ |
| description | Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of AA has become a research hotspot. Furthermore, the CYP metabolic pathway of AA is regulated by soluble epoxide hydrolase (sEH). 1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU) is a novel sEH inhibitor that exerts cerebrovascular protective activity. This article reviews the mechanism of TPPU's protective effect on ischemic stroke disease. |
| first_indexed | 2024-04-10T16:41:25Z |
| format | Article |
| id | doaj.art-c3ff9938ffa84e5d920de46454d60b80 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T16:41:25Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c3ff9938ffa84e5d920de46454d60b802023-02-08T07:02:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.10839721083972Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic strokePan HuangArachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of AA has become a research hotspot. Furthermore, the CYP metabolic pathway of AA is regulated by soluble epoxide hydrolase (sEH). 1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU) is a novel sEH inhibitor that exerts cerebrovascular protective activity. This article reviews the mechanism of TPPU's protective effect on ischemic stroke disease.https://www.frontiersin.org/articles/10.3389/fneur.2023.1083972/fullTPPUischemic strokeblood-brain barrierischemia reperfusionarachidonic acid |
| spellingShingle | Pan Huang Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke Frontiers in Neurology TPPU ischemic stroke blood-brain barrier ischemia reperfusion arachidonic acid |
| title | Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke |
| title_full | Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke |
| title_fullStr | Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke |
| title_full_unstemmed | Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke |
| title_short | Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke |
| title_sort | research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor tppu on ischemic stroke |
| topic | TPPU ischemic stroke blood-brain barrier ischemia reperfusion arachidonic acid |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1083972/full |
| work_keys_str_mv | AT panhuang researchprogressontheprotectivemechanismofanovelsolubleepoxidehydrolaseinhibitortppuonischemicstroke |