Oral manifestations of leukemia as part of early diagnosis
Introduction: The oral cavity can present the first clinical manifestations of leukemia, therefore; it is important to recognize their principal characteristics. Objective: To identify oral manifestations as the first clinical signs of leukemia. Methods: This is an integrative review, that gathered...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137921013092 |
| _version_ | 1828407037645553664 |
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| author | Reyna Aguilar Quispe Elizabeth Marques Aguiar Claudia Teresa de Oliveira Ana Cristina Xavier Neves Paulo Sérgio da Silva Santos |
| author_facet | Reyna Aguilar Quispe Elizabeth Marques Aguiar Claudia Teresa de Oliveira Ana Cristina Xavier Neves Paulo Sérgio da Silva Santos |
| author_sort | Reyna Aguilar Quispe |
| collection | DOAJ |
| description | Introduction: The oral cavity can present the first clinical manifestations of leukemia, therefore; it is important to recognize their principal characteristics. Objective: To identify oral manifestations as the first clinical signs of leukemia. Methods: This is an integrative review, that gathered data from articles with oral manifestations of leukemia as part of its first clinical features. The were included case reports, case series, clinical research, or reviews with case reports. The variables that were considered relevant: age, sex, sites of the oral lesions, characteristics of the oral lesions, medical history and physical examination, time of evolution, radiographic examination, blood test results, initial diagnosis, differential diagnosis and final diagnosis. Results: A total of 31 studies were included, with a total of 33 individuals identified. There were 19 (57.57%) males and 14 (42.42%) females. The age range was from 1.6 to 74 years. Acute myeloid leukemia (72.72%) and acute lymphoid leukemia (18.18%) presented more oral manifestations as the first clinical signs of the disease. All individuals with leukemia presented lesions, such as ulcer, erosion, bleeding, ecchymosis, color change of the bluish or pale mucous membranes and areas of tissue necrosis. Hard tissue lesions were less frequent, being 6 (18.18%). Conclusion: The first clinical manifestations of leukemia can be present in the oral cavity, mainly in acute myeloid leukemia. The principal oral tissues affected were gingival tissue, buccal mucosa and hard and/or soft palate. When hard tissues, such as the maxilla bone or mandible bone were affected, dental mobility was the principal clinical sign. |
| first_indexed | 2024-12-10T11:19:50Z |
| format | Article |
| id | doaj.art-c4002b6b3074459fb886a30378359949 |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-12-10T11:19:50Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-c4002b6b3074459fb886a303783599492022-12-22T01:51:01ZengElsevierHematology, Transfusion and Cell Therapy2531-13792022-07-01443392401Oral manifestations of leukemia as part of early diagnosisReyna Aguilar Quispe0Elizabeth Marques Aguiar1Claudia Teresa de Oliveira2Ana Cristina Xavier Neves3Paulo Sérgio da Silva Santos4Faculdade de Odontologia de Bauru da Universidade de São Paulo (FOB USP), Bauru, SP, Brazil; Corresponding author at: Department of Surgery, Stomatology, Pathology and Radiology, Alameda Dr. Otávio Pinheiro Brisola, 9-75, PC: 17012-901. Bauru, São Paulo, Brazil.Faculdade de Odontologia de Bauru da Universidade de São Paulo (FOB USP), Bauru, SP, BrazilHospital Estadual Bauru (HEB) Arnaldo Prado Curvelo, Bauru, SP, BrazilHospital Estadual Bauru (HEB) Arnaldo Prado Curvelo, Bauru, SP, BrazilFaculdade de Odontologia de Bauru da Universidade de São Paulo (FOB USP), Bauru, SP, BrazilIntroduction: The oral cavity can present the first clinical manifestations of leukemia, therefore; it is important to recognize their principal characteristics. Objective: To identify oral manifestations as the first clinical signs of leukemia. Methods: This is an integrative review, that gathered data from articles with oral manifestations of leukemia as part of its first clinical features. The were included case reports, case series, clinical research, or reviews with case reports. The variables that were considered relevant: age, sex, sites of the oral lesions, characteristics of the oral lesions, medical history and physical examination, time of evolution, radiographic examination, blood test results, initial diagnosis, differential diagnosis and final diagnosis. Results: A total of 31 studies were included, with a total of 33 individuals identified. There were 19 (57.57%) males and 14 (42.42%) females. The age range was from 1.6 to 74 years. Acute myeloid leukemia (72.72%) and acute lymphoid leukemia (18.18%) presented more oral manifestations as the first clinical signs of the disease. All individuals with leukemia presented lesions, such as ulcer, erosion, bleeding, ecchymosis, color change of the bluish or pale mucous membranes and areas of tissue necrosis. Hard tissue lesions were less frequent, being 6 (18.18%). Conclusion: The first clinical manifestations of leukemia can be present in the oral cavity, mainly in acute myeloid leukemia. The principal oral tissues affected were gingival tissue, buccal mucosa and hard and/or soft palate. When hard tissues, such as the maxilla bone or mandible bone were affected, dental mobility was the principal clinical sign.http://www.sciencedirect.com/science/article/pii/S2531137921013092LeukemiaDiagnosisOralMouthOral manifestations |
| spellingShingle | Reyna Aguilar Quispe Elizabeth Marques Aguiar Claudia Teresa de Oliveira Ana Cristina Xavier Neves Paulo Sérgio da Silva Santos Oral manifestations of leukemia as part of early diagnosis Hematology, Transfusion and Cell Therapy Leukemia Diagnosis Oral Mouth Oral manifestations |
| title | Oral manifestations of leukemia as part of early diagnosis |
| title_full | Oral manifestations of leukemia as part of early diagnosis |
| title_fullStr | Oral manifestations of leukemia as part of early diagnosis |
| title_full_unstemmed | Oral manifestations of leukemia as part of early diagnosis |
| title_short | Oral manifestations of leukemia as part of early diagnosis |
| title_sort | oral manifestations of leukemia as part of early diagnosis |
| topic | Leukemia Diagnosis Oral Mouth Oral manifestations |
| url | http://www.sciencedirect.com/science/article/pii/S2531137921013092 |
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