MARKERS OF SEVERE DESTRUCTION RHEUMATOID ARTHRITIS
In the examined patients with rheumatoid arthritis (RA), the VEGF level in blood was 2 times higher than the control and 30 % higher in the high-positive patients with anti-CCP. VEGF correlated with clinical parameters of severe RA, high disease activity, effusion to the joint cavity and hypervascul...
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| Format: | Article |
| Language: | Russian |
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Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
2017-12-01
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| Series: | Сеченовский вестник |
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| Online Access: | https://www.sechenovmedj.com/jour/article/view/38 |
| _version_ | 1797873742553022464 |
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| author | E. B. Komarova |
| author_facet | E. B. Komarova |
| author_sort | E. B. Komarova |
| collection | DOAJ |
| description | In the examined patients with rheumatoid arthritis (RA), the VEGF level in blood was 2 times higher than the control and 30 % higher in the high-positive patients with anti-CCP. VEGF correlated with clinical parameters of severe RA, high disease activity, effusion to the joint cavity and hypervascularization of the synovial lining. The concentration of FGF in the blood in RA patients was 2.5 times higher than control and 25 % higher in the high-positive patients with anti-CCP. FGF correlated with the duration of the disease, parameters of clinical course, the synovial thickening, the presence of pannus and osteochondral erosion. High levels of VEGF, FGF in the blood can be used as markers of severe destruction diseases in RA patients |
| first_indexed | 2024-04-10T01:20:00Z |
| format | Article |
| id | doaj.art-c4021736cf314a14af42ae39eb95edf8 |
| institution | Directory Open Access Journal |
| issn | 2218-7332 2658-3348 |
| language | Russian |
| last_indexed | 2024-04-10T01:20:00Z |
| publishDate | 2017-12-01 |
| publisher | Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) |
| record_format | Article |
| series | Сеченовский вестник |
| spelling | doaj.art-c4021736cf314a14af42ae39eb95edf82023-03-13T09:51:32ZrusFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Сеченовский вестник2218-73322658-33482017-12-0104303437MARKERS OF SEVERE DESTRUCTION RHEUMATOID ARTHRITISE. B. Komarova0State Institution «Lugansk State Medical University» of the Lugansk Peopleʼs RepublicIn the examined patients with rheumatoid arthritis (RA), the VEGF level in blood was 2 times higher than the control and 30 % higher in the high-positive patients with anti-CCP. VEGF correlated with clinical parameters of severe RA, high disease activity, effusion to the joint cavity and hypervascularization of the synovial lining. The concentration of FGF in the blood in RA patients was 2.5 times higher than control and 25 % higher in the high-positive patients with anti-CCP. FGF correlated with the duration of the disease, parameters of clinical course, the synovial thickening, the presence of pannus and osteochondral erosion. High levels of VEGF, FGF in the blood can be used as markers of severe destruction diseases in RA patientshttps://www.sechenovmedj.com/jour/article/view/38rheumatoid arthritisjoint destructionvascular endothelial growth factorfibroblast growth factorangiogenesis |
| spellingShingle | E. B. Komarova MARKERS OF SEVERE DESTRUCTION RHEUMATOID ARTHRITIS Сеченовский вестник rheumatoid arthritis joint destruction vascular endothelial growth factor fibroblast growth factor angiogenesis |
| title | MARKERS OF SEVERE DESTRUCTION RHEUMATOID ARTHRITIS |
| title_full | MARKERS OF SEVERE DESTRUCTION RHEUMATOID ARTHRITIS |
| title_fullStr | MARKERS OF SEVERE DESTRUCTION RHEUMATOID ARTHRITIS |
| title_full_unstemmed | MARKERS OF SEVERE DESTRUCTION RHEUMATOID ARTHRITIS |
| title_short | MARKERS OF SEVERE DESTRUCTION RHEUMATOID ARTHRITIS |
| title_sort | markers of severe destruction rheumatoid arthritis |
| topic | rheumatoid arthritis joint destruction vascular endothelial growth factor fibroblast growth factor angiogenesis |
| url | https://www.sechenovmedj.com/jour/article/view/38 |
| work_keys_str_mv | AT ebkomarova markersofseveredestructionrheumatoidarthritis |