| Summary: | Analysis of the chemical components from the culture broth of the marine bacterium <i>Saccharomonospora</i> sp. CNQ-490 has yielded three novel compounds: saccharobisindole (<b>1</b>), neoasterric methyl ester (<b>2</b>), and 7-chloro-4(<i>1H</i>)-quinolone (<b>3</b>), in addition to acremonidine E (<b>4</b>), pinselin (<b>5</b>), penicitrinon A (<b>6</b>), and penicitrinon E (<b>7</b>). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data. Compound <b>2</b> generated weak inhibition activity against <i>Bacillus subtilis</i> KCTC2441 and <i>Staphylococcus aureus</i> KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds <b>1</b> and <b>3</b> did not have any observable effects. In addition, compound <b>2</b> displayed weak anti-quorum sensing (QS) effects against <i>S. aureus</i> KCTC1927 and <i>Micrococcus luteus</i> SCO560.
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