Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment
<p>Abstract</p> <p>Background -</p> <p>Traditional Chinese Medicine (TCM) has been used for thousands of years to treat or prevent diseases, including cancer. Good manufacturing practices (GMP) and sophisticated product analysis (PhytomicsQC) to ensure consistency are n...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-05-01
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| Series: | BMC Medical Genomics |
| Online Access: | http://www.biomedcentral.com/1755-8794/4/38 |
| _version_ | 1818880115676807168 |
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| author | Stroncek David F Zhao Yingdong Mark Yichao Jiang Zaoli Guan Fulan Lam Wing Bedognetti Davide Quinn Courtney Bussom Scott Chen Jinguo Wang Ena White Jeffrey Marincola Francesco M Cheng Yung-Chi |
| author_facet | Stroncek David F Zhao Yingdong Mark Yichao Jiang Zaoli Guan Fulan Lam Wing Bedognetti Davide Quinn Courtney Bussom Scott Chen Jinguo Wang Ena White Jeffrey Marincola Francesco M Cheng Yung-Chi |
| author_sort | Stroncek David F |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background -</p> <p>Traditional Chinese Medicine (TCM) has been used for thousands of years to treat or prevent diseases, including cancer. Good manufacturing practices (GMP) and sophisticated product analysis (PhytomicsQC) to ensure consistency are now available allowing the assessment of its utility. Polychemical Medicines, like TCM, include chemicals with distinct tissue-dependent pharmacodynamic properties that result in tissue-specific bioactivity. Determining the mode of action of these mixtures was previously unsatisfactory; however, information rich RNA microarray technologies now allow for thorough mechanistic studies of the effects complex mixtures. PHY906 is a long used four herb TCM formula employed as an adjuvant to relieve the side effects associated with chemotherapy. Animal studies documented a decrease in global toxicity and an increase in therapeutic effectiveness of chemotherapy when combined with PHY906.</p> <p>Methods -</p> <p>Using a systems biology approach, we studied tumor tissue to identify reasons for the enhancement of the antitumor effect of CPT-11 (CPT-11) by PHY906 in a well-characterized pre-clinical model; the administration of PHY906 and CPT-11 to female BDF-1 mice bearing subcutaneous Colon 38 tumors.</p> <p>Results -</p> <p>We observed that 1) individually PHY906 and CPT-11 induce distinct alterations in tumor, liver and spleen; 2) PHY906 alone predominantly induces repression of transcription and immune-suppression in tumors; 3) these effects are reverted in the presence of CPT-11, with prevalent induction of pro-apoptotic and pro-inflammatory pathways that may favor tumor rejection.</p> <p>Conclusions -</p> <p>PHY906 together with CPT-11 triggers unique changes not activated by each one alone suggesting that the combination creates a unique tissue-specific response.</p> |
| first_indexed | 2024-12-19T14:40:50Z |
| format | Article |
| id | doaj.art-c402ac07e1254248a4d1963e2f3a069f |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-12-19T14:40:50Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-c402ac07e1254248a4d1963e2f3a069f2022-12-21T20:17:05ZengBMCBMC Medical Genomics1755-87942011-05-01413810.1186/1755-8794-4-38Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironmentStroncek David FZhao YingdongMark YichaoJiang ZaoliGuan FulanLam WingBedognetti DavideQuinn CourtneyBussom ScottChen JinguoWang EnaWhite JeffreyMarincola Francesco MCheng Yung-Chi<p>Abstract</p> <p>Background -</p> <p>Traditional Chinese Medicine (TCM) has been used for thousands of years to treat or prevent diseases, including cancer. Good manufacturing practices (GMP) and sophisticated product analysis (PhytomicsQC) to ensure consistency are now available allowing the assessment of its utility. Polychemical Medicines, like TCM, include chemicals with distinct tissue-dependent pharmacodynamic properties that result in tissue-specific bioactivity. Determining the mode of action of these mixtures was previously unsatisfactory; however, information rich RNA microarray technologies now allow for thorough mechanistic studies of the effects complex mixtures. PHY906 is a long used four herb TCM formula employed as an adjuvant to relieve the side effects associated with chemotherapy. Animal studies documented a decrease in global toxicity and an increase in therapeutic effectiveness of chemotherapy when combined with PHY906.</p> <p>Methods -</p> <p>Using a systems biology approach, we studied tumor tissue to identify reasons for the enhancement of the antitumor effect of CPT-11 (CPT-11) by PHY906 in a well-characterized pre-clinical model; the administration of PHY906 and CPT-11 to female BDF-1 mice bearing subcutaneous Colon 38 tumors.</p> <p>Results -</p> <p>We observed that 1) individually PHY906 and CPT-11 induce distinct alterations in tumor, liver and spleen; 2) PHY906 alone predominantly induces repression of transcription and immune-suppression in tumors; 3) these effects are reverted in the presence of CPT-11, with prevalent induction of pro-apoptotic and pro-inflammatory pathways that may favor tumor rejection.</p> <p>Conclusions -</p> <p>PHY906 together with CPT-11 triggers unique changes not activated by each one alone suggesting that the combination creates a unique tissue-specific response.</p>http://www.biomedcentral.com/1755-8794/4/38 |
| spellingShingle | Stroncek David F Zhao Yingdong Mark Yichao Jiang Zaoli Guan Fulan Lam Wing Bedognetti Davide Quinn Courtney Bussom Scott Chen Jinguo Wang Ena White Jeffrey Marincola Francesco M Cheng Yung-Chi Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment BMC Medical Genomics |
| title | Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment |
| title_full | Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment |
| title_fullStr | Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment |
| title_full_unstemmed | Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment |
| title_short | Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment |
| title_sort | interaction of a traditional chinese medicine phy906 and cpt 11 on the inflammatory process in the tumor microenvironment |
| url | http://www.biomedcentral.com/1755-8794/4/38 |
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