Are multiple courses of antibiotics a potential risk factor for COVID-19 infection and severity?
Background: To determine the potential risk factor of COVID-19 severity and length of hospitalization, the association between multiple antibiotics administration and the risk of severe COVID-19. Methods: A case-control study of 58 hospitalized COVID-19 patients (the case group) and 120 non-hospital...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | One Health Bulletin |
| Subjects: | |
| Online Access: | http://www.johb.info/article.asp?issn=2773-0344;year=2023;volume=3;issue=1;spage=10;epage=10;aulast=Shams |
| _version_ | 1797322252178423808 |
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| author | Maiada Mahmoud Shams Ebthal Mamdouh Hamdy Dina Fawzy Abd-elsadek |
| author_facet | Maiada Mahmoud Shams Ebthal Mamdouh Hamdy Dina Fawzy Abd-elsadek |
| author_sort | Maiada Mahmoud Shams |
| collection | DOAJ |
| description | Background: To determine the potential risk factor of COVID-19 severity and length of hospitalization, the association between multiple antibiotics administration and the risk of severe COVID-19.
Methods: A case-control study of 58 hospitalized COVID-19 patients (the case group) and 120 non-hospitalized home isolated COVID-19 patients (the control group) was conducted. Data were collected using hospital medical records and verbal questionnaires for the participants.
Results: Totally 89.2% of non-hospitalized mild COVID-19 patients received ⩽2 courses of antibiotics/year, while 36.0% of hospitalized patients received ⩾4 courses of antibiotics, 56.9% received 2-3 courses of antibiotics/year and only 6.9% of them were exposed to ⩽2 courses of antibiotics/year. our study emphasizes that the usage of 4 courses or higher per year was a significant risk factor for hospitalization [OR: 17.5; 95%CI(2.596-118.263); P=0.003], while the usage of ⩽2 courses was a preventive predictor for severity and hospitalization [OR: 0.072; 95%CI(0.006-0.900); P=0.041]. Furthermore, age was associated with 8.4% increase in the odds of severe COVID-19 [OR: 1.084; 95%CI(1.024-1.148), P=0.005], and females were 89.1% less likely to hospitalized than males [OR: 0.109; 95%CI(0.024-0.498); P= 0.004]. Our study shows that 70.4% of cases misused antibiotics and administered the antibiotics themselves without a physician’s prescription. Around 50.0% of cases never completed the ideal duration of the course in contrast to controls, of which only 23.2% did not complete the ideal duration.
Conclusions: Our study shows that antibiotics misuse and overuse may be a potential risk factor for COVID-19 severity and hospitalization. |
| first_indexed | 2024-03-08T05:11:31Z |
| format | Article |
| id | doaj.art-c404023b7e444df4800128cc8db6fcb9 |
| institution | Directory Open Access Journal |
| issn | 2773-0344 2773-0352 |
| language | English |
| last_indexed | 2024-03-08T05:11:31Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | One Health Bulletin |
| spelling | doaj.art-c404023b7e444df4800128cc8db6fcb92024-02-07T09:12:57ZengWolters Kluwer Medknow PublicationsOne Health Bulletin2773-03442773-03522023-01-0131101010.4103/2773-0344.378589Are multiple courses of antibiotics a potential risk factor for COVID-19 infection and severity?Maiada Mahmoud ShamsEbthal Mamdouh HamdyDina Fawzy Abd-elsadekBackground: To determine the potential risk factor of COVID-19 severity and length of hospitalization, the association between multiple antibiotics administration and the risk of severe COVID-19. Methods: A case-control study of 58 hospitalized COVID-19 patients (the case group) and 120 non-hospitalized home isolated COVID-19 patients (the control group) was conducted. Data were collected using hospital medical records and verbal questionnaires for the participants. Results: Totally 89.2% of non-hospitalized mild COVID-19 patients received ⩽2 courses of antibiotics/year, while 36.0% of hospitalized patients received ⩾4 courses of antibiotics, 56.9% received 2-3 courses of antibiotics/year and only 6.9% of them were exposed to ⩽2 courses of antibiotics/year. our study emphasizes that the usage of 4 courses or higher per year was a significant risk factor for hospitalization [OR: 17.5; 95%CI(2.596-118.263); P=0.003], while the usage of ⩽2 courses was a preventive predictor for severity and hospitalization [OR: 0.072; 95%CI(0.006-0.900); P=0.041]. Furthermore, age was associated with 8.4% increase in the odds of severe COVID-19 [OR: 1.084; 95%CI(1.024-1.148), P=0.005], and females were 89.1% less likely to hospitalized than males [OR: 0.109; 95%CI(0.024-0.498); P= 0.004]. Our study shows that 70.4% of cases misused antibiotics and administered the antibiotics themselves without a physician’s prescription. Around 50.0% of cases never completed the ideal duration of the course in contrast to controls, of which only 23.2% did not complete the ideal duration. Conclusions: Our study shows that antibiotics misuse and overuse may be a potential risk factor for COVID-19 severity and hospitalization.http://www.johb.info/article.asp?issn=2773-0344;year=2023;volume=3;issue=1;spage=10;epage=10;aulast=Shamscovid-19 severity; antibiotic frequent administration; previous antibiotic exposure |
| spellingShingle | Maiada Mahmoud Shams Ebthal Mamdouh Hamdy Dina Fawzy Abd-elsadek Are multiple courses of antibiotics a potential risk factor for COVID-19 infection and severity? One Health Bulletin covid-19 severity; antibiotic frequent administration; previous antibiotic exposure |
| title | Are multiple courses of antibiotics a potential risk factor for COVID-19 infection and severity? |
| title_full | Are multiple courses of antibiotics a potential risk factor for COVID-19 infection and severity? |
| title_fullStr | Are multiple courses of antibiotics a potential risk factor for COVID-19 infection and severity? |
| title_full_unstemmed | Are multiple courses of antibiotics a potential risk factor for COVID-19 infection and severity? |
| title_short | Are multiple courses of antibiotics a potential risk factor for COVID-19 infection and severity? |
| title_sort | are multiple courses of antibiotics a potential risk factor for covid 19 infection and severity |
| topic | covid-19 severity; antibiotic frequent administration; previous antibiotic exposure |
| url | http://www.johb.info/article.asp?issn=2773-0344;year=2023;volume=3;issue=1;spage=10;epage=10;aulast=Shams |
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