The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels

The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels

The bovine pancreatic trypsin inhibitor (BPTI)-Kunitz-type protein ShPI-1 (UniProt: P31713) is the major protease inhibitor from the sea anemone Stichodactyla helianthus. This molecule is used in biotechnology and has biomedical potential related to its anti-parasitic effect. A pseudo wild-type vari...

Full description

Bibliographic Details
Main Authors:	Rossana García-Fernández, Steve Peigneur, Tirso Pons, Carlos Alvarez, Lidice González, María A. Chávez, Jan Tytgat
Format:	Article
Language:	English
Published:	MDPI AG 2016-04-01
Series:	Toxins
Subjects:	protease inhibitor Kv channel inhibitor sea anemone toxin Kunitz-type protein
Online Access:	http://www.mdpi.com/2072-6651/8/4/110

Similar Items

Atypical Reactive Center Kunitz-Type Inhibitor from the Sea Anemone <em>Heteractis crispa</em>
by: Emma Kozlovkaya, et al.
Published: (2012-07-01)

Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model
by: Oksana Sintsova, et al.
Published: (2021-03-01)

New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa
by: Irina Gladkikh, et al.
Published: (2015-09-01)

Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets
by: Camila Ramalho Bonturi, et al.
Published: (2022-04-01)

Expression of the First Recombinant Anti-Tumoral Snake Venom Kunitz-Type Serine Protease Inhibitor
by: Maram Morjen, et al.
Published: (2022-02-01)

The complex world of plant protease inhibitors: Insights into a Kunitz-type cysteine protease inhibitor of Arabidopsis thaliana
by: Sachin Rustgi, et al.
Published: (2018-01-01)

Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor
by: Margarita Monastyrnaya, et al.
Published: (2016-12-01)

Molecular Characterization of Kunitz-Type Protease Inhibitors from Blister Beetles (Coleoptera, Meloidae)
by: Emiliano Fratini, et al.
Published: (2022-07-01)

Kunitz Soybean Trypsin Inhibitor is Modified at its C-terminus by Novel Soybean Thiol Protease (Protease T1)
by: Makoto Sugawara, et al.
Published: (2007-01-01)

Kunitz-Type Peptides from the Sea Anemone <i>Heteractis crispa</i> Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities
by: Irina Gladkikh, et al.
Published: (2020-11-01)

Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni
by: Shiwanthi L. Ranasinghe, et al.
Published: (2015-08-01)

A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases
by: Roberto Tadashi Kodama, et al.
Published: (2020-10-01)

Laura: Soybean variety lacking Kunitz trypsin inhibitor
by: Srebrić Mirjana, et al.
Published: (2010-01-01)

Effect of thermally untreated soybean with low levels of Kunitz trypsin inhibitors in the diet of broilers
by: Beuković Dejan, et al.
Published: (2011-01-01)

Tick Salivary Kunitz-Type Inhibitors: Targeting Host Hemostasis and Immunity to Mediate Successful Blood Feeding
by: Mohamed Amine Jmel, et al.
Published: (2023-01-01)

Protease Inhibitors from Marine Venomous Animals and Their Counterparts in Terrestrial Venomous Animals
by: Caroline B. F. Mourão, et al.
Published: (2013-06-01)

Identification of soybean Kunitz-free progenies in full-sib crossing
by: Srebrić Mirjana, et al.
Published: (2020-01-01)

A Retrospective Analysis of the Cartilage Kunitz Protease Inhibitory Proteins Identifies These as Members of the Inter-α-Trypsin Inhibitor Superfamily with Potential Roles in the Protection of the Articulatory Surface
by: Susan M. Smith, et al.
Published: (2019-01-01)

Intestinal Exposure to Food-Derived Protease Inhibitors: Digestion Physiology- and Gut Health-Related Effects
by: Anna Kårlund, et al.
Published: (2021-08-01)

Bowman-Birk inhibitor in soybean: Genetic variability in relation to total trypsin inhibitor activity and elimination of Kunitz trypsin inhibitor
by: Priyanka MITTAL, et al.
Published: (2021-03-01)

The First Anti-Snakebite and Hepatoprotective Characterization of a Trypsin Kunitz-like Inhibitor (EcTI) from the Plant <i>Enterolobium contortisiliquum;</i> A Case of Two Soul Mates Meeting
by: Caroline R. C. Costa, et al.
Published: (2023-04-01)

Targeting Secreted Protease/Anti-Protease Balance as a Vaccine Strategy against the Helminth <i>Fasciola hepatica</i>
by: Krystyna Cwiklinski, et al.
Published: (2022-01-01)

Partial purification of trypsin inhibitors from Parkia seeds (Fabaceae)
by: Larissa Ramos Chevreuil, et al.
Published: (2014-06-01)

APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1
by: Lien Moreels, et al.
Published: (2017-09-01)

Polar Desolvation and Position 226 of Pancreatic and Neutrophil Elastases Are Crucial to their Affinity for the Kunitz-Type Inhibitors ShPI-1 and ShPI-1/K13L.
by: Jorge Enrique Hernández González, et al.
Published: (2015-01-01)

Molecular cloning, functional assessment and transcriptome characterization of cysteine protease inhibitor and kunitz trypsin inhibitor from turmeric (Curcuma longa L.)
by: Chan, Seow Neng
Published: (2016)

Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson’s Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation
by: Aleksandra Kvetkina, et al.
Published: (2022-05-01)

A Low Molecular Weight Protein from the Sea Anemone Anemonia viridis with an Anti-Angiogenic Activity
by: Erwann P. Loret, et al.
Published: (2018-04-01)

Bioinformatic comparison of Kunitz protease inhibitors in Echinococcus granulosus sensu stricto and E. multilocularis and the genes expressed in different developmental stages of E. granulosus s.s.
by: Hui Zhang, et al.
Published: (2021-12-01)

Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells
by: Mariana Costa Braga Schmidt, et al.
Published: (2020-01-01)

Structure–Activity Relationship and Molecular Docking of a Kunitz-Like Trypsin Inhibitor, Kunitzin-AH, from the Skin Secretion of <i>Amolops hainanensis</i>
by: Yuqing Chen, et al.
Published: (2021-06-01)

Peptides Derived of Kunitz-Type Serine Protease Inhibitor as Potential Vaccine Against Experimental Schistosomiasis
by: Juan Hernández-Goenaga, et al.
Published: (2019-11-01)

Kunitz Proteinase Inhibitors Limit Water Stress Responses in White Clover (Trifolium repens L.) Plants
by: Afsana Islam, et al.
Published: (2017-10-01)

Kunitz-type protease inhibitor as a vaccine candidate against schistosomiasis mansoni
by: Shiwanthi L. Ranasinghe, et al.
Published: (2018-01-01)

Changes in storage protein composition on genetic removal of Kunitz trypsin inhibitor maintain protein content in soybean (Glycine max)
by: Anita Rani, et al.
Published: (2020-12-01)

Thermostable serine protease inhibitor from Death cap (Amanita phalloides)
by: phichaya khamai, et al.
Published: (2019-06-01)

Snake Venom: A Promising Source of Neurotoxins Targeting Voltage-Gated Potassium Channels
by: Altaf K. AlShammari, et al.
Published: (2023-12-01)

Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
by: Amiram Sananes, et al.
Published: (2023-11-01)

Development of Breeder-Friendly KASP Markers for Low Concentration of Kunitz Trypsin Inhibitor in Soybean Seeds
by: M. Luciana Rosso, et al.
Published: (2021-03-01)

Schistosome serine protease inhibitors: parasite defense or homeostasis?
by: Landys A. Lopez Quezada, et al.
Published: (2011-06-01)