Therapeutic potential of berberine in attenuating cholestatic liver injury: insights from a PSC mouse model

Therapeutic potential of berberine in attenuating cholestatic liver injury: insights from a PSC mouse model

Abstract Background and aims Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by progressive biliary inflammation and bile duct injury. Berberine (BBR) is a bioactive isoquinoline alkaloid found in various herbs and has multiple beneficial effects on metabolic and inflam...

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Bibliographic Details
Main Authors: Yanyan Wang, Derrick Zhao, Lianyong Su, Yun-Ling Tai, Grayson W. Way, Jing Zeng, Qianhua Yan, Ying Xu, Xuan Wang, Emily C. Gurley, Xi-Qiao Zhou, Jinze Liu, Jinpeng Liu, Weidong Chen, Phillip B. Hylemon, Huiping Zhou
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell & Bioscience
Subjects:
Bile acids
Cholestasis
Inflammation
Berberine
Gut microbiome
Online Access:https://doi.org/10.1186/s13578-024-01195-8

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