Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures
Abstract The emergence of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses significant challenges to global public health. Despite the extensive efforts of researchers worldwide, there remains considerable opportunities for improvement in timely diagnosis, specific treatment,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-01945-9 |
| _version_ | 1797795539493847040 |
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| author | Jia Wang Qingpeng Xie Haoyue Song Xiaohang Chen Xiaoxuan Zhang Xiangyu Zhao Yujia Hao Yuan Zhang Huifei Li Na Li Kelong Fan Xing Wang |
| author_facet | Jia Wang Qingpeng Xie Haoyue Song Xiaohang Chen Xiaoxuan Zhang Xiangyu Zhao Yujia Hao Yuan Zhang Huifei Li Na Li Kelong Fan Xing Wang |
| author_sort | Jia Wang |
| collection | DOAJ |
| description | Abstract The emergence of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses significant challenges to global public health. Despite the extensive efforts of researchers worldwide, there remains considerable opportunities for improvement in timely diagnosis, specific treatment, and effective vaccines for SARS-CoV-2. This is due, in part, to the large number of asymptomatic carriers, rapid virus mutations, inconsistent confinement policies, untimely diagnosis and limited clear treatment plans. The emerging of nanozymes offers a promising approach for combating SARS-CoV-2 due to their stable physicochemical properties and high surface areas, which enable easier and multiple nano-bio interactions in vivo. Nanozymes inspire the development of sensitive and economic nanosensors for rapid detection, facilitate the development of specific medicines with minimal side effects for targeted therapy, trigger defensive mechanisms in the form of vaccines, and eliminate SARS-CoV-2 in the environment for prevention. In this review, we briefly present the limitations of existing countermeasures against coronavirus disease 2019 (COVID-19). We then reviewed the applications of nanozyme-based platforms in the fields of diagnostics, therapeutics and the prevention in COVID-19. Finally, we propose opportunities and challenges for the further development of nanozyme-based platforms for COVID-19. We expect that our review will provide valuable insights into the new emerging and re-emerging infectious pandemic from the perspective of nanozymes. Graphical Abstract |
| first_indexed | 2024-03-13T03:19:30Z |
| format | Article |
| id | doaj.art-c410a0028f0046188e0102b10575d811 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-13T03:19:30Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-c410a0028f0046188e0102b10575d8112023-06-25T11:26:46ZengBMCJournal of Nanobiotechnology1477-31552023-06-0121111610.1186/s12951-023-01945-9Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measuresJia Wang0Qingpeng Xie1Haoyue Song2Xiaohang Chen3Xiaoxuan Zhang4Xiangyu Zhao5Yujia Hao6Yuan Zhang7Huifei Li8Na Li9Kelong Fan10Xing Wang11Shanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyCAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of SciencesShanxi Medical University School and Hospital of StomatologyAbstract The emergence of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses significant challenges to global public health. Despite the extensive efforts of researchers worldwide, there remains considerable opportunities for improvement in timely diagnosis, specific treatment, and effective vaccines for SARS-CoV-2. This is due, in part, to the large number of asymptomatic carriers, rapid virus mutations, inconsistent confinement policies, untimely diagnosis and limited clear treatment plans. The emerging of nanozymes offers a promising approach for combating SARS-CoV-2 due to their stable physicochemical properties and high surface areas, which enable easier and multiple nano-bio interactions in vivo. Nanozymes inspire the development of sensitive and economic nanosensors for rapid detection, facilitate the development of specific medicines with minimal side effects for targeted therapy, trigger defensive mechanisms in the form of vaccines, and eliminate SARS-CoV-2 in the environment for prevention. In this review, we briefly present the limitations of existing countermeasures against coronavirus disease 2019 (COVID-19). We then reviewed the applications of nanozyme-based platforms in the fields of diagnostics, therapeutics and the prevention in COVID-19. Finally, we propose opportunities and challenges for the further development of nanozyme-based platforms for COVID-19. We expect that our review will provide valuable insights into the new emerging and re-emerging infectious pandemic from the perspective of nanozymes. Graphical Abstracthttps://doi.org/10.1186/s12951-023-01945-9NanozymesCOVID-19SARS-CoV-2Nanomedicine |
| spellingShingle | Jia Wang Qingpeng Xie Haoyue Song Xiaohang Chen Xiaoxuan Zhang Xiangyu Zhao Yujia Hao Yuan Zhang Huifei Li Na Li Kelong Fan Xing Wang Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures Journal of Nanobiotechnology Nanozymes COVID-19 SARS-CoV-2 Nanomedicine |
| title | Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures |
| title_full | Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures |
| title_fullStr | Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures |
| title_full_unstemmed | Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures |
| title_short | Utilizing nanozymes for combating COVID-19: advancements in diagnostics, treatments, and preventative measures |
| title_sort | utilizing nanozymes for combating covid 19 advancements in diagnostics treatments and preventative measures |
| topic | Nanozymes COVID-19 SARS-CoV-2 Nanomedicine |
| url | https://doi.org/10.1186/s12951-023-01945-9 |
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