Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral Lesions
Objective: To compare Methylene blue and Lugol’s Iodine as6an adjunctive tool6for early diagnosis of premalignant oral6lesions by taking histopathology as gold standard. Methods: In this cross-sectional study patients of oral0premalignant lesions were selected. Methylene blue and lugols iodine...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Rawalpindi Medical University
2019-05-01
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| Series: | Journal of Rawalpindi Medical College |
| Subjects: | |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/1107 |
| _version_ | 1818110646549479424 |
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| author | Surwaich Ali Arhama Surwaich Muhammad Muslim Khakro |
| author_facet | Surwaich Ali Arhama Surwaich Muhammad Muslim Khakro |
| author_sort | Surwaich Ali |
| collection | DOAJ |
| description | Objective: To compare Methylene blue and
Lugol’s Iodine as6an adjunctive tool6for early
diagnosis of premalignant oral6lesions by taking
histopathology as gold standard.
Methods: In this cross-sectional study patients of
oral0premalignant lesions were selected. Methylene
blue and lugols iodine staining was used at lesion’s
area. Mucosa0of target site was dried gently by
gauze0and power0air0spray with triple syringe to
make sure that the0lesion is not0being contaminated
with0saliva. The dye was applied directly with a
cotton0bud for 10-20 seconds and was decolorized.
The dye retention pattern was evaluated by stain
retention’s intensity on the lesion. Incisional biopsy
was performed simultaneously from that site as gold
standard.
Results: Out of 60 cases, males were 81.6%.
Majority (65.0%) had more than one addicting habit
of mainpuri, gutka and supari. The commonest
region of oral lesions was the buccal6mucosa
(61.6%). According to the diagnostic accuracy of
methylene blue the sensitivity was 89.4% and
specificity was 66.6%. According to the Lugol’s
Iodine sensitivity was 83.3% and specificity was
50%.
Conclusion: Methylene blue and lugols iodine
staining are an easy and non-invasive screening tools
for the early diagnosis of malignancy. |
| first_indexed | 2024-12-11T02:50:27Z |
| format | Article |
| id | doaj.art-c413e542ce734ee29f8c01c6af9eeacf |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-12-11T02:50:27Z |
| publishDate | 2019-05-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-c413e542ce734ee29f8c01c6af9eeacf2022-12-22T01:23:20ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702019-05-01232Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral LesionsSurwaich Ali0Arhama Surwaich1Muhammad Muslim Khakro2Oral Pathology Department Isra Dental College Hyderabad;Oral Pathology Department Isra Dental College HyderabadDental Material Department,LUMHS Jamshoro HyderabadObjective: To compare Methylene blue and Lugol’s Iodine as6an adjunctive tool6for early diagnosis of premalignant oral6lesions by taking histopathology as gold standard. Methods: In this cross-sectional study patients of oral0premalignant lesions were selected. Methylene blue and lugols iodine staining was used at lesion’s area. Mucosa0of target site was dried gently by gauze0and power0air0spray with triple syringe to make sure that the0lesion is not0being contaminated with0saliva. The dye was applied directly with a cotton0bud for 10-20 seconds and was decolorized. The dye retention pattern was evaluated by stain retention’s intensity on the lesion. Incisional biopsy was performed simultaneously from that site as gold standard. Results: Out of 60 cases, males were 81.6%. Majority (65.0%) had more than one addicting habit of mainpuri, gutka and supari. The commonest region of oral lesions was the buccal6mucosa (61.6%). According to the diagnostic accuracy of methylene blue the sensitivity was 89.4% and specificity was 66.6%. According to the Lugol’s Iodine sensitivity was 83.3% and specificity was 50%. Conclusion: Methylene blue and lugols iodine staining are an easy and non-invasive screening tools for the early diagnosis of malignancy.https://www.journalrmc.com/index.php/JRMC/article/view/1107Premalignant and malignant lesionsMethylene blueLugol’s IodineOral Cavity |
| spellingShingle | Surwaich Ali Arhama Surwaich Muhammad Muslim Khakro Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral Lesions Journal of Rawalpindi Medical College Premalignant and malignant lesions Methylene blue Lugol’s Iodine Oral Cavity |
| title | Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral Lesions |
| title_full | Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral Lesions |
| title_fullStr | Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral Lesions |
| title_full_unstemmed | Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral Lesions |
| title_short | Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral Lesions |
| title_sort | methylene blue and lugol s iodine as an adjunctive tool for early diagnosis of premalignant oral lesions |
| topic | Premalignant and malignant lesions Methylene blue Lugol’s Iodine Oral Cavity |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/1107 |
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