Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy
8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we measured the 8-OHdG/8-OHG levels in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multip...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2002-03-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996102904663 |
| _version_ | 1819161057123368960 |
|---|---|
| author | Akio Kikuchi Atsushi Takeda Hiroshi Onodera Teiko Kimpara Kinya Hisanaga Nobuyuki Sato Akihiko Nunomura Rudy J. Castellani George Perry Mark A. Smith Yasuto Itoyama |
| author_facet | Akio Kikuchi Atsushi Takeda Hiroshi Onodera Teiko Kimpara Kinya Hisanaga Nobuyuki Sato Akihiko Nunomura Rudy J. Castellani George Perry Mark A. Smith Yasuto Itoyama |
| author_sort | Akio Kikuchi |
| collection | DOAJ |
| description | 8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we measured the 8-OHdG/8-OHG levels in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Compared to age-matched controls, the mean levels of serum 8-OHdG/8-OHG were significantly higher in PD (P < 0.0001). Although no gender differences were observed in the controls, the mean values of serum 8-OHdG/8-OHG were significantly higher in female PD cases (P < 0.005) than in male patients. 8-OHdG/8-OHG levels in CSF were also increased significantly in patients with PD and MSA, however, their relative values were generally much lower than those in the serum. Together with previous studies showing increased peripheral 8-OHdG levels in Alzheimer's disease and amyotrophic lateral sclerosis, the data presented here suggest that systemic DNA/RNA oxidation is commonly observed in neurodegenerative diseases. Our results also imply that female patients with PD show higher levels of oxidative stress, which may explain the faster progression of this disease in females. |
| first_indexed | 2024-12-22T17:06:17Z |
| format | Article |
| id | doaj.art-c414901199444011b3d3881e4159a2a1 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-22T17:06:17Z |
| publishDate | 2002-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-c414901199444011b3d3881e4159a2a12022-12-21T18:19:11ZengElsevierNeurobiology of Disease1095-953X2002-03-0192244248Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System AtrophyAkio Kikuchi0Atsushi Takeda1Hiroshi Onodera2Teiko Kimpara3Kinya Hisanaga4Nobuyuki Sato5Akihiko Nunomura6Rudy J. Castellani7George Perry8Mark A. Smith9Yasuto Itoyama10Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OhioDepartment of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we measured the 8-OHdG/8-OHG levels in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Compared to age-matched controls, the mean levels of serum 8-OHdG/8-OHG were significantly higher in PD (P < 0.0001). Although no gender differences were observed in the controls, the mean values of serum 8-OHdG/8-OHG were significantly higher in female PD cases (P < 0.005) than in male patients. 8-OHdG/8-OHG levels in CSF were also increased significantly in patients with PD and MSA, however, their relative values were generally much lower than those in the serum. Together with previous studies showing increased peripheral 8-OHdG levels in Alzheimer's disease and amyotrophic lateral sclerosis, the data presented here suggest that systemic DNA/RNA oxidation is commonly observed in neurodegenerative diseases. Our results also imply that female patients with PD show higher levels of oxidative stress, which may explain the faster progression of this disease in females.http://www.sciencedirect.com/science/article/pii/S0969996102904663Parkinson's diseaseoxidative stress8-hydroxy-2′-deoxyguanosine (8-OHdG) /8-hydroxyguanosine (8-OHG) |
| spellingShingle | Akio Kikuchi Atsushi Takeda Hiroshi Onodera Teiko Kimpara Kinya Hisanaga Nobuyuki Sato Akihiko Nunomura Rudy J. Castellani George Perry Mark A. Smith Yasuto Itoyama Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy Neurobiology of Disease Parkinson's disease oxidative stress 8-hydroxy-2′-deoxyguanosine (8-OHdG) /8-hydroxyguanosine (8-OHG) |
| title | Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy |
| title_full | Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy |
| title_fullStr | Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy |
| title_full_unstemmed | Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy |
| title_short | Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy |
| title_sort | systemic increase of oxidative nucleic acid damage in parkinson s disease and multiple system atrophy |
| topic | Parkinson's disease oxidative stress 8-hydroxy-2′-deoxyguanosine (8-OHdG) /8-hydroxyguanosine (8-OHG) |
| url | http://www.sciencedirect.com/science/article/pii/S0969996102904663 |
| work_keys_str_mv | AT akiokikuchi systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT atsushitakeda systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT hiroshionodera systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT teikokimpara systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT kinyahisanaga systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT nobuyukisato systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT akihikonunomura systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT rudyjcastellani systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT georgeperry systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT markasmith systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy AT yasutoitoyama systemicincreaseofoxidativenucleicaciddamageinparkinsonsdiseaseandmultiplesystematrophy |