A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

Abstract Background Osteoporosis (OP) patients complicated with type II diabetes mellitus (T2DM) has a higher fracture risk than the non-diabetic patients, and mesenchymal stem cells (MSCs) from T2DM patients also show a weaker osteogenic potent. The present study aimed to provide a gene expression...

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Bibliographic Details
Main Authors: Sheng-li Xia, Zi-yuan Ma, Bin Wang, Feng Gao, Sheng-yang Guo, Xu-han Chen
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
T2DM
Osteoporosis
FOXQ1
Osteogenic differentiation
Mesenchymal stem cells
Online Access:https://doi.org/10.1186/s13018-022-03291-2

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