Biological Activity of Naturally Derived Naphthyridines
Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/14/4324 |
| _version_ | 1797526479121154048 |
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| author | Gabriela Chabowska Ewa Barg Anna Wójcicka |
| author_facet | Gabriela Chabowska Ewa Barg Anna Wójcicka |
| author_sort | Gabriela Chabowska |
| collection | DOAJ |
| description | Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes. |
| first_indexed | 2024-03-10T09:30:51Z |
| format | Article |
| id | doaj.art-c415a8f8e9804fbbbfb3103f968b6d39 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:30:51Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c415a8f8e9804fbbbfb3103f968b6d392023-11-22T04:32:04ZengMDPI AGMolecules1420-30492021-07-012614432410.3390/molecules26144324Biological Activity of Naturally Derived NaphthyridinesGabriela Chabowska0Ewa Barg1Anna Wójcicka2Department of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, PolandDepartment of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, PolandMarine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes.https://www.mdpi.com/1420-3049/26/14/4324natural compoundsalkaloidsnaphthyridinesheterocyclic compoundscanthin-6-oneaaptamine |
| spellingShingle | Gabriela Chabowska Ewa Barg Anna Wójcicka Biological Activity of Naturally Derived Naphthyridines Molecules natural compounds alkaloids naphthyridines heterocyclic compounds canthin-6-one aaptamine |
| title | Biological Activity of Naturally Derived Naphthyridines |
| title_full | Biological Activity of Naturally Derived Naphthyridines |
| title_fullStr | Biological Activity of Naturally Derived Naphthyridines |
| title_full_unstemmed | Biological Activity of Naturally Derived Naphthyridines |
| title_short | Biological Activity of Naturally Derived Naphthyridines |
| title_sort | biological activity of naturally derived naphthyridines |
| topic | natural compounds alkaloids naphthyridines heterocyclic compounds canthin-6-one aaptamine |
| url | https://www.mdpi.com/1420-3049/26/14/4324 |
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