Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report
Background: Allergic rhinitis is a common inflammatory nasal mucosal disease characterized by sneezing, watery nasal discharge, nasal obstruction and itching. Although allergen-specific antibodies play a main role in the allergic airway inflammation, neuronal inflammation may also contribute to the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-12-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=185 |
| _version_ | 1797910670956560384 |
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| author | Onur İsmi Cengiz Özcan Yusuf Vayisoğlu Kemal Görür Tuba Karabacak Gürbüz Polat Taylan Güçlütürk |
| author_facet | Onur İsmi Cengiz Özcan Yusuf Vayisoğlu Kemal Görür Tuba Karabacak Gürbüz Polat Taylan Güçlütürk |
| author_sort | Onur İsmi |
| collection | DOAJ |
| description | Background: Allergic rhinitis is a common inflammatory nasal mucosal disease characterized by sneezing, watery nasal discharge, nasal obstruction and itching. Although allergen-specific antibodies play a main role in the allergic airway inflammation, neuronal inflammation may also contribute to the symptoms of allergic rhinitis. Neuronal inflammation is primarily caused by the stimulation of sensory nerve endings with histamine. It has been shown that neurotrophins may also have a role in allergic reactions and neuronal inflammation. Nerve growth factor, neurotrophin 3 (NT-3), neurotrophin 4/5 and brain-derived neurotrophic factor are members of the neurotrophin family. Although nerve growth factor and brain-derived neurotrophic factor are well studied in allergic rhinitis patients, the exact role of Neurotrophin-3 is not known.
Aims: To investigate the possible roles of neurotrophin-3 in allergic rhinitis patients.
Study Design: Case-control study.
Methods: Neurotrophin-3 levels were studied in the inferior turbinate and serum samples of 20 allergic rhinitis and 13 control patients. Neurotrophin-3 staining of nasal tissues was evaluated by immunohistochemistry and ELISA was used for the determination of serum Neurotrophin-3 levels.
Results: Neurotrophin-3 staining scores were statistically higher in the study group than in the control patients (p=0.001). Regarding serum Neurotrophin-3 levels, no statistically significant difference could be determined between allergic rhinitis and control patients (p=0.156). When comparing the serum NT-3 levels with tissue staining scores, there were no statistically significant differences in the allergic rhinitis and control groups (p=0.254 for allergic rhinitis and p=0.624 for control groups).
Conclusion: We suggest that Neurotrophin-3 might affect the nasal mucosa locally without being released into the systemic circulation in allergic rhinitis patients. |
| first_indexed | 2024-04-10T11:28:05Z |
| format | Article |
| id | doaj.art-c415cc3b101c40f7bbeb607e64f15f5e |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T11:28:05Z |
| publishDate | 2015-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-c415cc3b101c40f7bbeb607e64f15f5e2023-02-15T16:18:15ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312015-12-0132436437010.5152/balkanmedj.2015.151028Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary ReportOnur İsmi0Cengiz Özcan1Yusuf Vayisoğlu2Kemal Görür3Tuba Karabacak4Gürbüz Polat5Taylan Güçlütürk6Department of Otorhinolaryngology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Otorhinolaryngology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Otorhinolaryngology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Otorhinolaryngology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Pathology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medical Biochemistry, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Otorhinolaryngology, Gaziantep State Hospital, Gaziantep, TurkeyBackground: Allergic rhinitis is a common inflammatory nasal mucosal disease characterized by sneezing, watery nasal discharge, nasal obstruction and itching. Although allergen-specific antibodies play a main role in the allergic airway inflammation, neuronal inflammation may also contribute to the symptoms of allergic rhinitis. Neuronal inflammation is primarily caused by the stimulation of sensory nerve endings with histamine. It has been shown that neurotrophins may also have a role in allergic reactions and neuronal inflammation. Nerve growth factor, neurotrophin 3 (NT-3), neurotrophin 4/5 and brain-derived neurotrophic factor are members of the neurotrophin family. Although nerve growth factor and brain-derived neurotrophic factor are well studied in allergic rhinitis patients, the exact role of Neurotrophin-3 is not known. Aims: To investigate the possible roles of neurotrophin-3 in allergic rhinitis patients. Study Design: Case-control study. Methods: Neurotrophin-3 levels were studied in the inferior turbinate and serum samples of 20 allergic rhinitis and 13 control patients. Neurotrophin-3 staining of nasal tissues was evaluated by immunohistochemistry and ELISA was used for the determination of serum Neurotrophin-3 levels. Results: Neurotrophin-3 staining scores were statistically higher in the study group than in the control patients (p=0.001). Regarding serum Neurotrophin-3 levels, no statistically significant difference could be determined between allergic rhinitis and control patients (p=0.156). When comparing the serum NT-3 levels with tissue staining scores, there were no statistically significant differences in the allergic rhinitis and control groups (p=0.254 for allergic rhinitis and p=0.624 for control groups). Conclusion: We suggest that Neurotrophin-3 might affect the nasal mucosa locally without being released into the systemic circulation in allergic rhinitis patients.http://balkanmedicaljournal.org/text.php?lang=en&id=185Airwayallergic rhinitisinflammationneuronalneurotrophin-3rhinitis |
| spellingShingle | Onur İsmi Cengiz Özcan Yusuf Vayisoğlu Kemal Görür Tuba Karabacak Gürbüz Polat Taylan Güçlütürk Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report Balkan Medical Journal Airway allergic rhinitis inflammation neuronal neurotrophin-3 rhinitis |
| title | Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report |
| title_full | Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report |
| title_fullStr | Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report |
| title_full_unstemmed | Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report |
| title_short | Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report |
| title_sort | local effect of neurotrophin 3 in neuronal inflammation of allergic rhinitis preliminary report |
| topic | Airway allergic rhinitis inflammation neuronal neurotrophin-3 rhinitis |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=185 |
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