Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed
Milk production phenotypes are the main focus of genetic selection in dairy herds, and although there are many genes identified as related to the biology of these traits in pure breeds, little is known about crossbreed animals. This study aimed to identify potential genes associated with the 305-day...
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2020.573344/full |
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| author | Alex Silva da Cruz Danilo Conrado Silva Lysa Bernardes Minasi Larissa Kamídia de Farias Teixeira Flávia Melo Rodrigues Claudio Carlos da Silva Adriana Santana do Carmo Marcos Vinicius Gualberto Barbosa da Silva Yuri Tani Utsunomiya José Fernando Garcia Aparecido Divino da Cruz |
| author_facet | Alex Silva da Cruz Danilo Conrado Silva Lysa Bernardes Minasi Larissa Kamídia de Farias Teixeira Flávia Melo Rodrigues Claudio Carlos da Silva Adriana Santana do Carmo Marcos Vinicius Gualberto Barbosa da Silva Yuri Tani Utsunomiya José Fernando Garcia Aparecido Divino da Cruz |
| author_sort | Alex Silva da Cruz |
| collection | DOAJ |
| description | Milk production phenotypes are the main focus of genetic selection in dairy herds, and although there are many genes identified as related to the biology of these traits in pure breeds, little is known about crossbreed animals. This study aimed to identify potential genes associated with the 305-day milk yield in 337 crossbreed Gir × Holstein (Girolando) animals. Milk production records were genotyped for 45,613 single-nucleotide polymorphisms (SNPs). This dataset was used for a genome-wide association study (GWAS) using the 305-day milk yield adjusted for the fixed effects of herd and year and linear and quadratic effects of age at calving (in days) and calving factor averaged per animal. Genes within the significant SNPs were retrieved from the Bos taurus ARS-UCD1.2 assembly (bosTau9) for gene ontology analysis. In summary, the GWAS identified 52 SNPs associated [p ≤ 10–4, false discovery rate (FDR) = 8.77%] with milk production, including NUB1 and SLC24A2, which were previously described as related to milk production traits in cattle. The results suggest that SNPs associated mainly with NUB1 and SLC24A2 could be useful to understand milk production in Girolando and used as predictive markers for selecting genetic predisposition for milk yield in Girolando. |
| first_indexed | 2024-12-16T13:19:43Z |
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| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-16T13:19:43Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-c415f5f216a649449b29f6a2975a86862022-12-21T22:30:23ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-01-011110.3389/fgene.2020.573344573344Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando CrossbreedAlex Silva da Cruz0Danilo Conrado Silva1Lysa Bernardes Minasi2Larissa Kamídia de Farias Teixeira3Flávia Melo Rodrigues4Claudio Carlos da Silva5Adriana Santana do Carmo6Marcos Vinicius Gualberto Barbosa da Silva7Yuri Tani Utsunomiya8José Fernando Garcia9Aparecido Divino da Cruz10Mestrado em Genética, Núcleo de Pesquisas Replicon, Escola de Ciências Agrárias e Biológicas, Pontifícia Universidade Católica de Goiás, Goiânia, BrazilCurso de Graduação em Medicina Veterinária, Instituto Acadêmico de Ciências Agrárias e Sustentabilidade, Universidade Estadual de Goiás, São Luís de Montes Belos, BrazilMestrado em Genética, Núcleo de Pesquisas Replicon, Escola de Ciências Agrárias e Biológicas, Pontifícia Universidade Católica de Goiás, Goiânia, BrazilMestrado em Genética, Núcleo de Pesquisas Replicon, Escola de Ciências Agrárias e Biológicas, Pontifícia Universidade Católica de Goiás, Goiânia, BrazilMestrado em Genética, Núcleo de Pesquisas Replicon, Escola de Ciências Agrárias e Biológicas, Pontifícia Universidade Católica de Goiás, Goiânia, BrazilMestrado em Genética, Núcleo de Pesquisas Replicon, Escola de Ciências Agrárias e Biológicas, Pontifícia Universidade Católica de Goiás, Goiânia, BrazilEscola de Veterinária e Zootecnia, Departamento de Zootecnia, Universidade Federal de Goiás, Goiânia, BrazilEmpresa Brazileira de Pesquisa Agropecuária, Centro Nacional de Pesquisa de Gado de Leite, Juiz de Fora, BrazilDepartamento de Apoio a Produção e Saúde Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista Júlio de Mesquita Filho, Araçatuba, BrazilDepartamento de Apoio a Produção e Saúde Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista Júlio de Mesquita Filho, Araçatuba, BrazilMestrado em Genética, Núcleo de Pesquisas Replicon, Escola de Ciências Agrárias e Biológicas, Pontifícia Universidade Católica de Goiás, Goiânia, BrazilMilk production phenotypes are the main focus of genetic selection in dairy herds, and although there are many genes identified as related to the biology of these traits in pure breeds, little is known about crossbreed animals. This study aimed to identify potential genes associated with the 305-day milk yield in 337 crossbreed Gir × Holstein (Girolando) animals. Milk production records were genotyped for 45,613 single-nucleotide polymorphisms (SNPs). This dataset was used for a genome-wide association study (GWAS) using the 305-day milk yield adjusted for the fixed effects of herd and year and linear and quadratic effects of age at calving (in days) and calving factor averaged per animal. Genes within the significant SNPs were retrieved from the Bos taurus ARS-UCD1.2 assembly (bosTau9) for gene ontology analysis. In summary, the GWAS identified 52 SNPs associated [p ≤ 10–4, false discovery rate (FDR) = 8.77%] with milk production, including NUB1 and SLC24A2, which were previously described as related to milk production traits in cattle. The results suggest that SNPs associated mainly with NUB1 and SLC24A2 could be useful to understand milk production in Girolando and used as predictive markers for selecting genetic predisposition for milk yield in Girolando.https://www.frontiersin.org/articles/10.3389/fgene.2020.573344/fullSNPdairy cattleindicineGWASselection |
| spellingShingle | Alex Silva da Cruz Danilo Conrado Silva Lysa Bernardes Minasi Larissa Kamídia de Farias Teixeira Flávia Melo Rodrigues Claudio Carlos da Silva Adriana Santana do Carmo Marcos Vinicius Gualberto Barbosa da Silva Yuri Tani Utsunomiya José Fernando Garcia Aparecido Divino da Cruz Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed Frontiers in Genetics SNP dairy cattle indicine GWAS selection |
| title | Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed |
| title_full | Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed |
| title_fullStr | Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed |
| title_full_unstemmed | Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed |
| title_short | Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed |
| title_sort | single nucleotide polymorphism variations associated with specific genes putatively identified enhanced genetic predisposition for 305 day milk yield in the girolando crossbreed |
| topic | SNP dairy cattle indicine GWAS selection |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2020.573344/full |
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