Crystal engineering of ionic cocrystals comprising Na/K salts of hesperetin with hesperetin molecules and solubility modulation

Crystal engineering of ionic cocrystals comprising Na/K salts of hesperetin with hesperetin molecules and solubility modulation

Hesperetin (HES) is a weakly acidic flavonoid of topical interest owing to its antiviral properties. Despite the presence of HES in many dietary supplements, its bioavailability is hindered by poor aqueous solubility (1.35 µg ml−1) and rapid first-pass metabolism. Cocrystallization has evolved as a...

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Bibliographic Details
Main Authors: Shasha Jin, Molly M. Haskins, Cheng-Hua Deng, Catiúcia R. M. O. Matos, Michael J. Zaworotko
Format: Article
Language:English
Published: International Union of Crystallography 2023-05-01
Series:IUCrJ
Subjects:
crystal engineering
ionic cocrystals
phenol–phenolate synthons
nutraceuticals
molecular crystals
Online Access:http://scripts.iucr.org/cgi-bin/paper?S205225252300266X

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http://scripts.iucr.org/cgi-bin/paper?S205225252300266X

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