PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA
PWP1 is a chromatin binding protein with an important role in animal growth control downstream of mTOR-mediated nutrient sensing. PWP1 has been shown to control tissue growth by promoting the transcription of 5.8S, 18S and 28S ribosomal RNAs (rRNAs) by RNA polymerase I (Pol I). Concomitantly with Po...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2018-11-01
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| Series: | Biology Open |
| Subjects: | |
| Online Access: | http://bio.biologists.org/content/7/11/bio037911 |
| _version_ | 1819071091572736000 |
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| author | Ying Liu Rita Cerejeira Matos Tapio I. Heino Ville Hietakangas |
| author_facet | Ying Liu Rita Cerejeira Matos Tapio I. Heino Ville Hietakangas |
| author_sort | Ying Liu |
| collection | DOAJ |
| description | PWP1 is a chromatin binding protein with an important role in animal growth control downstream of mTOR-mediated nutrient sensing. PWP1 has been shown to control tissue growth by promoting the transcription of 5.8S, 18S and 28S ribosomal RNAs (rRNAs) by RNA polymerase I (Pol I). Concomitantly with Pol I, RNA Polymerase III (Pol III) contributes to ribosome biogenesis by transcribing 5S rRNA in the nucleoplasm. Pol III activity is also closely controlled by nutrient-dependent signaling, however, how the activities of Pol I and Pol III are coordinated in response to nutrient-derived signals remains insufficiently understood. Experiments in Drosophila larvae and human cells reported here show that PWP1 associates with the chromatin at the 5S rDNA loci and is needed for nutrient-induced expression of 5S rRNA. Similar to the Pol I target rDNAs, PWP1 epigenetically maintains 5S rDNA in a transcription competent state. Thus, as a common regulator of Pol I and Pol III, PWP1 might contribute to coordinated control of ribosomal gene expression in response to nutrition. This article has an associated First Person interview with the first author of the paper. |
| first_indexed | 2024-12-21T17:16:19Z |
| format | Article |
| id | doaj.art-c419a54fdfea4736a361d72525e8e26b |
| institution | Directory Open Access Journal |
| issn | 2046-6390 |
| language | English |
| last_indexed | 2024-12-21T17:16:19Z |
| publishDate | 2018-11-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Biology Open |
| spelling | doaj.art-c419a54fdfea4736a361d72525e8e26b2022-12-21T18:56:17ZengThe Company of BiologistsBiology Open2046-63902018-11-0171110.1242/bio.037911037911PWP1 promotes nutrient-responsive expression of 5S ribosomal RNAYing Liu0Rita Cerejeira Matos1Tapio I. Heino2Ville Hietakangas3 Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland PWP1 is a chromatin binding protein with an important role in animal growth control downstream of mTOR-mediated nutrient sensing. PWP1 has been shown to control tissue growth by promoting the transcription of 5.8S, 18S and 28S ribosomal RNAs (rRNAs) by RNA polymerase I (Pol I). Concomitantly with Pol I, RNA Polymerase III (Pol III) contributes to ribosome biogenesis by transcribing 5S rRNA in the nucleoplasm. Pol III activity is also closely controlled by nutrient-dependent signaling, however, how the activities of Pol I and Pol III are coordinated in response to nutrient-derived signals remains insufficiently understood. Experiments in Drosophila larvae and human cells reported here show that PWP1 associates with the chromatin at the 5S rDNA loci and is needed for nutrient-induced expression of 5S rRNA. Similar to the Pol I target rDNAs, PWP1 epigenetically maintains 5S rDNA in a transcription competent state. Thus, as a common regulator of Pol I and Pol III, PWP1 might contribute to coordinated control of ribosomal gene expression in response to nutrition. This article has an associated First Person interview with the first author of the paper.http://bio.biologists.org/content/7/11/bio037911PWP1NCLBNutrient5S ribosomal RNATranscriptionRNA polymerase III |
| spellingShingle | Ying Liu Rita Cerejeira Matos Tapio I. Heino Ville Hietakangas PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA Biology Open PWP1 NCLB Nutrient 5S ribosomal RNA Transcription RNA polymerase III |
| title | PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA |
| title_full | PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA |
| title_fullStr | PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA |
| title_full_unstemmed | PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA |
| title_short | PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA |
| title_sort | pwp1 promotes nutrient responsive expression of 5s ribosomal rna |
| topic | PWP1 NCLB Nutrient 5S ribosomal RNA Transcription RNA polymerase III |
| url | http://bio.biologists.org/content/7/11/bio037911 |
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