Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation
Atrial fibrillation is the most frequent arrhythmia in adults, becoming more frequent with age. Recent clinical studies demonstrated that epicardial fat is linked with atrial fibrillation induction and recurrence. The arrhythmogenic mechanism consists in the fact that the epicardial adipose tissue i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-12-01
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| Series: | Journal of Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/jim-2017-0090 |
| _version_ | 1818720590664564736 |
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| author | Rat Nora Mitre Adriana Korodi Szilamér Benedek István Lázár Erzsébet Kéri Johanna Pakucs Annamária Benedek István |
| author_facet | Rat Nora Mitre Adriana Korodi Szilamér Benedek István Lázár Erzsébet Kéri Johanna Pakucs Annamária Benedek István |
| author_sort | Rat Nora |
| collection | DOAJ |
| description | Atrial fibrillation is the most frequent arrhythmia in adults, becoming more frequent with age. Recent clinical studies demonstrated that epicardial fat is linked with atrial fibrillation induction and recurrence. The arrhythmogenic mechanism consists in the fact that the epicardial adipose tissue is metabolically active, inducing local inflammation and enhancing the oxidative stress, which lead to atrial fibrillation as well as atherosclerosis. Having metabolic activity and secreting various anti- and pro-inflammatory biomarkers, the fat surrounding the heart has been linked to the complex process of coronary plaque vulnerabilization. This clinical update aims to summarize the role of epicardial adipose tissue in the pathogenesis, persistence, and severity of atrial fibrillation. |
| first_indexed | 2024-12-17T20:25:16Z |
| format | Article |
| id | doaj.art-c41a67b573cc460a8b11b44ea689660d |
| institution | Directory Open Access Journal |
| issn | 2501-8132 |
| language | English |
| last_indexed | 2024-12-17T20:25:16Z |
| publishDate | 2017-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Interdisciplinary Medicine |
| spelling | doaj.art-c41a67b573cc460a8b11b44ea689660d2022-12-21T21:33:49ZengSciendoJournal of Interdisciplinary Medicine2501-81322017-12-012430430710.1515/jim-2017-0090jim-2017-0090Epicardial Fat, Paracrine-mediated Inflammation and Atrial FibrillationRat Nora0Mitre Adriana1Korodi Szilamér2Benedek István3Lázár Erzsébet4Kéri Johanna5Pakucs Annamária6Benedek István7University of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaUniversity of Medicine and Pharmacy, Tîrgu Mureș, RomaniaAtrial fibrillation is the most frequent arrhythmia in adults, becoming more frequent with age. Recent clinical studies demonstrated that epicardial fat is linked with atrial fibrillation induction and recurrence. The arrhythmogenic mechanism consists in the fact that the epicardial adipose tissue is metabolically active, inducing local inflammation and enhancing the oxidative stress, which lead to atrial fibrillation as well as atherosclerosis. Having metabolic activity and secreting various anti- and pro-inflammatory biomarkers, the fat surrounding the heart has been linked to the complex process of coronary plaque vulnerabilization. This clinical update aims to summarize the role of epicardial adipose tissue in the pathogenesis, persistence, and severity of atrial fibrillation.https://doi.org/10.1515/jim-2017-0090atrial fibrillationpericardial fatinflammationnoninvasive cardiac imaging |
| spellingShingle | Rat Nora Mitre Adriana Korodi Szilamér Benedek István Lázár Erzsébet Kéri Johanna Pakucs Annamária Benedek István Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation Journal of Interdisciplinary Medicine atrial fibrillation pericardial fat inflammation noninvasive cardiac imaging |
| title | Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation |
| title_full | Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation |
| title_fullStr | Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation |
| title_full_unstemmed | Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation |
| title_short | Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation |
| title_sort | epicardial fat paracrine mediated inflammation and atrial fibrillation |
| topic | atrial fibrillation pericardial fat inflammation noninvasive cardiac imaging |
| url | https://doi.org/10.1515/jim-2017-0090 |
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