Analysis of circulating tumor DNA: a new concept in clinical oncology
In recent years ,scientific and technological oncologie advances had allowed the emergence of a new concept which tends to become a new model in medicine; personalized medicine, capable to analyze the genomic specificities of each individual, to better meet their needs. Indeed, it is currently poss...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University of Oran 1
2021-12-01
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| Series: | Journal de la Faculté de Médecine d'Oran |
| Subjects: | |
| Online Access: | https://www.ajol.info/index.php/jfmo/article/view/226759 |
| _version_ | 1797741150907400192 |
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| author | Mourad NACHI Ibtissem KIHEL |
| author_facet | Mourad NACHI Ibtissem KIHEL |
| author_sort | Mourad NACHI |
| collection | DOAJ |
| description |
In recent years ,scientific and technological oncologie advances had allowed the emergence of a new concept which tends to become a new model in medicine; personalized medicine, capable to analyze the genomic specificities of each individual, to better meet their needs.
Indeed, it is currently possible to detect and quantify in blood «liquid biopsy» without invasive act compared to tissue biopsy, several biomarkers as circulating tumor DNA (ctDNA), circulating tumor cells and circulating micro-RNA, with three major potential applications:
early detection and diagnosis of cancers, estimation and quantitative monitoring of tumor burden; and the detection of mutations that may possibly be predictive of response or resistance to treatment.
In this article, we will focus on the role of circulating tumor DNA in the early diagnosis, therapeutic monitoring, prognosis and prediction of response to treatment in colorectal, non-small cell lung cancers (CRC, NSCLC) and breast cancer.
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| first_indexed | 2024-03-12T14:22:45Z |
| format | Article |
| id | doaj.art-c41b0aa9919a4323ae52dc7db79c4681 |
| institution | Directory Open Access Journal |
| issn | 2571-9874 2602-6511 |
| language | English |
| last_indexed | 2024-03-12T14:22:45Z |
| publishDate | 2021-12-01 |
| publisher | University of Oran 1 |
| record_format | Article |
| series | Journal de la Faculté de Médecine d'Oran |
| spelling | doaj.art-c41b0aa9919a4323ae52dc7db79c46812023-08-18T19:41:53ZengUniversity of Oran 1Journal de la Faculté de Médecine d'Oran2571-98742602-65112021-12-0152Analysis of circulating tumor DNA: a new concept in clinical oncologyMourad NACHI0Ibtissem KIHEL1Laboratoire de Recherche de Biochimie Médicale et de Biologie Moléculaire, Faculté de Médecine, Université Oran1Laboratoire de Recherche de Biochimie Médicale et de Biologie Moléculaire, Faculté de Médecine, Université Oran1 In recent years ,scientific and technological oncologie advances had allowed the emergence of a new concept which tends to become a new model in medicine; personalized medicine, capable to analyze the genomic specificities of each individual, to better meet their needs. Indeed, it is currently possible to detect and quantify in blood «liquid biopsy» without invasive act compared to tissue biopsy, several biomarkers as circulating tumor DNA (ctDNA), circulating tumor cells and circulating micro-RNA, with three major potential applications: early detection and diagnosis of cancers, estimation and quantitative monitoring of tumor burden; and the detection of mutations that may possibly be predictive of response or resistance to treatment. In this article, we will focus on the role of circulating tumor DNA in the early diagnosis, therapeutic monitoring, prognosis and prediction of response to treatment in colorectal, non-small cell lung cancers (CRC, NSCLC) and breast cancer. https://www.ajol.info/index.php/jfmo/article/view/226759Liquid biopsyctDNANS-CLCCRCBreast cancer |
| spellingShingle | Mourad NACHI Ibtissem KIHEL Analysis of circulating tumor DNA: a new concept in clinical oncology Journal de la Faculté de Médecine d'Oran Liquid biopsy ctDNA NS-CLC CRC Breast cancer |
| title | Analysis of circulating tumor DNA: a new concept in clinical oncology |
| title_full | Analysis of circulating tumor DNA: a new concept in clinical oncology |
| title_fullStr | Analysis of circulating tumor DNA: a new concept in clinical oncology |
| title_full_unstemmed | Analysis of circulating tumor DNA: a new concept in clinical oncology |
| title_short | Analysis of circulating tumor DNA: a new concept in clinical oncology |
| title_sort | analysis of circulating tumor dna a new concept in clinical oncology |
| topic | Liquid biopsy ctDNA NS-CLC CRC Breast cancer |
| url | https://www.ajol.info/index.php/jfmo/article/view/226759 |
| work_keys_str_mv | AT mouradnachi analysisofcirculatingtumordnaanewconceptinclinicaloncology AT ibtissemkihel analysisofcirculatingtumordnaanewconceptinclinicaloncology |