Limbal Stem Cell Allografts and Corneal Transplant in a Patient with Severe Corneal Melting and Perforation due to Thermokeratoplasty andCross-Linking Treatment Burn
Purpose: To report corneal stem cell allografts in a patient with a persistent epithelial defect as well as corneal melting and perforation due to severe ultraviolet light burn and thermokeratoplasty treatment for keratoconus. Methods: A 21-year-old female patient with corneal melting, perforation a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2012-10-01
|
| Series: | Case Reports in Ophthalmology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/343771 |
| _version_ | 1819159737383518208 |
|---|---|
| author | Leopoldo Garduño-Vieyra Claudia Ruth Gonzalez Sergio E. Hernandez-Da Mota |
| author_facet | Leopoldo Garduño-Vieyra Claudia Ruth Gonzalez Sergio E. Hernandez-Da Mota |
| author_sort | Leopoldo Garduño-Vieyra |
| collection | DOAJ |
| description | Purpose: To report corneal stem cell allografts in a patient with a persistent epithelial defect as well as corneal melting and perforation due to severe ultraviolet light burn and thermokeratoplasty treatment for keratoconus. Methods: A 21-year-old female patient with corneal melting, perforation and a persistent epithelial defect in her left eye secondary to iatrogenic treatment for keratoconus, thermokeratoplasty and cross-linking was treated with penetrating keratoplasty, using a 9.0-mm diameter corneal graft and limbal stem cell allograft implants. At the end of the procedure, subtenonian injections of a combination of bevacizumab and triamcinolone were given. Results: The patient had a favorable outcome 48 h after surgery, with an improvement of symptoms and a complete corneal healing. By the third week after surgery, she had a best-corrected visual acuity of 20/60 and a clear corneal graft, which remained stable for the 9 months of follow-up. Conclusions: Treatment with limbal stem cell allografts and penetrating keratoplasty in a female patient with a large corneal defect and melting in her left eye was effective. Larger studies are warranted to explore the real impact of this procedure. |
| first_indexed | 2024-12-22T16:45:18Z |
| format | Article |
| id | doaj.art-c41b1844f3314ef69ac06e5b284424dc |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-12-22T16:45:18Z |
| publishDate | 2012-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-c41b1844f3314ef69ac06e5b284424dc2022-12-21T18:19:45ZengKarger PublishersCase Reports in Ophthalmology1663-26992012-10-013336436910.1159/000343771343771Limbal Stem Cell Allografts and Corneal Transplant in a Patient with Severe Corneal Melting and Perforation due to Thermokeratoplasty andCross-Linking Treatment BurnLeopoldo Garduño-VieyraClaudia Ruth GonzalezSergio E. Hernandez-Da MotaPurpose: To report corneal stem cell allografts in a patient with a persistent epithelial defect as well as corneal melting and perforation due to severe ultraviolet light burn and thermokeratoplasty treatment for keratoconus. Methods: A 21-year-old female patient with corneal melting, perforation and a persistent epithelial defect in her left eye secondary to iatrogenic treatment for keratoconus, thermokeratoplasty and cross-linking was treated with penetrating keratoplasty, using a 9.0-mm diameter corneal graft and limbal stem cell allograft implants. At the end of the procedure, subtenonian injections of a combination of bevacizumab and triamcinolone were given. Results: The patient had a favorable outcome 48 h after surgery, with an improvement of symptoms and a complete corneal healing. By the third week after surgery, she had a best-corrected visual acuity of 20/60 and a clear corneal graft, which remained stable for the 9 months of follow-up. Conclusions: Treatment with limbal stem cell allografts and penetrating keratoplasty in a female patient with a large corneal defect and melting in her left eye was effective. Larger studies are warranted to explore the real impact of this procedure.http://www.karger.com/Article/FullText/343771Stem cellsCorneal meltingThermokeratoplastyThermal burn |
| spellingShingle | Leopoldo Garduño-Vieyra Claudia Ruth Gonzalez Sergio E. Hernandez-Da Mota Limbal Stem Cell Allografts and Corneal Transplant in a Patient with Severe Corneal Melting and Perforation due to Thermokeratoplasty andCross-Linking Treatment Burn Case Reports in Ophthalmology Stem cells Corneal melting Thermokeratoplasty Thermal burn |
| title | Limbal Stem Cell Allografts and Corneal Transplant in a Patient with Severe Corneal Melting and Perforation due to Thermokeratoplasty andCross-Linking Treatment Burn |
| title_full | Limbal Stem Cell Allografts and Corneal Transplant in a Patient with Severe Corneal Melting and Perforation due to Thermokeratoplasty andCross-Linking Treatment Burn |
| title_fullStr | Limbal Stem Cell Allografts and Corneal Transplant in a Patient with Severe Corneal Melting and Perforation due to Thermokeratoplasty andCross-Linking Treatment Burn |
| title_full_unstemmed | Limbal Stem Cell Allografts and Corneal Transplant in a Patient with Severe Corneal Melting and Perforation due to Thermokeratoplasty andCross-Linking Treatment Burn |
| title_short | Limbal Stem Cell Allografts and Corneal Transplant in a Patient with Severe Corneal Melting and Perforation due to Thermokeratoplasty andCross-Linking Treatment Burn |
| title_sort | limbal stem cell allografts and corneal transplant in a patient with severe corneal melting and perforation due to thermokeratoplasty andcross linking treatment burn |
| topic | Stem cells Corneal melting Thermokeratoplasty Thermal burn |
| url | http://www.karger.com/Article/FullText/343771 |
| work_keys_str_mv | AT leopoldogardunovieyra limbalstemcellallograftsandcornealtransplantinapatientwithseverecornealmeltingandperforationduetothermokeratoplastyandcrosslinkingtreatmentburn AT claudiaruthgonzalez limbalstemcellallograftsandcornealtransplantinapatientwithseverecornealmeltingandperforationduetothermokeratoplastyandcrosslinkingtreatmentburn AT sergioehernandezdamota limbalstemcellallograftsandcornealtransplantinapatientwithseverecornealmeltingandperforationduetothermokeratoplastyandcrosslinkingtreatmentburn |