Polycationic Glycosides
Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical a...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/16/2/1508/ |
| _version_ | 1818919192405999616 |
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| author | Karin Melkonian Erika Testani Faiza Sheikh JaimeLee Rizzo Lisa-Marie Nisbett Christopher Awad Eva Cere Daniel Ambinder Craig Capodiferro Heidi Lee Leah Rothman Jay Leb Laura Friedman Barbara Klaritch-Vrana Alejandra Castaño Marie Thomas Diego Montenegro Robert Engel Ishrat Ghani |
| author_facet | Karin Melkonian Erika Testani Faiza Sheikh JaimeLee Rizzo Lisa-Marie Nisbett Christopher Awad Eva Cere Daniel Ambinder Craig Capodiferro Heidi Lee Leah Rothman Jay Leb Laura Friedman Barbara Klaritch-Vrana Alejandra Castaño Marie Thomas Diego Montenegro Robert Engel Ishrat Ghani |
| author_sort | Karin Melkonian |
| collection | DOAJ |
| description | Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented. |
| first_indexed | 2024-12-20T01:01:57Z |
| format | Article |
| id | doaj.art-c41c36fda88f48209c6926d0b137e5bd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T01:01:57Z |
| publishDate | 2011-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c41c36fda88f48209c6926d0b137e5bd2022-12-21T19:58:58ZengMDPI AGMolecules1420-30492011-02-011621508151810.3390/molecules16021508Polycationic GlycosidesKarin MelkonianErika TestaniFaiza SheikhJaimeLee RizzoLisa-Marie NisbettChristopher AwadEva CereDaniel AmbinderCraig CapodiferroHeidi LeeLeah RothmanJay LebLaura FriedmanBarbara Klaritch-VranaAlejandra CastañoMarie ThomasDiego MontenegroRobert EngelIshrat GhaniCationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.http://www.mdpi.com/1420-3049/16/2/1508/polycationic lipidglycosidecyclodextrinstarch1,4-diazabicyclo[2.2.2]-octaneantibacterial |
| spellingShingle | Karin Melkonian Erika Testani Faiza Sheikh JaimeLee Rizzo Lisa-Marie Nisbett Christopher Awad Eva Cere Daniel Ambinder Craig Capodiferro Heidi Lee Leah Rothman Jay Leb Laura Friedman Barbara Klaritch-Vrana Alejandra Castaño Marie Thomas Diego Montenegro Robert Engel Ishrat Ghani Polycationic Glycosides Molecules polycationic lipid glycoside cyclodextrin starch 1,4-diazabicyclo[2.2.2]-octane antibacterial |
| title | Polycationic Glycosides |
| title_full | Polycationic Glycosides |
| title_fullStr | Polycationic Glycosides |
| title_full_unstemmed | Polycationic Glycosides |
| title_short | Polycationic Glycosides |
| title_sort | polycationic glycosides |
| topic | polycationic lipid glycoside cyclodextrin starch 1,4-diazabicyclo[2.2.2]-octane antibacterial |
| url | http://www.mdpi.com/1420-3049/16/2/1508/ |
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