Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket

Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket

Calmodulin (CaM) is a small, multifunctional calcium (Ca<sup>2+</sup>)-binding sensor that binds and regulates the open probability of cardiac ryanodine receptor 2 (RyR2) at both low and high cytosolic Ca<sup>2+</sup> concentrations. Recent isothermal titration calorimetry (I...

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Bibliographic Details
Main Authors: Angelos Thanassoulas, Maria Theodoridou, Laila Barrak, Emna Riguene, Tamader Alyaarabi, Mohamed A. Elrayess, F. Anthony Lai, Michail Nomikos
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
calmodulin
ryanodine receptor
RyR2
arrhythmias
cardiac disease
Online Access:https://www.mdpi.com/1422-0067/24/21/15630

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