How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative model

How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative model

Abstract Background Wide evidence suggests that physical activity (PA) confers protection against Alzheimer’s disease (AD). On the other hand, the apolipoprotein E gene (APOE) ε4 allele represents the greatest genetic risk factor for developing AD. Extensive research has been conducted to determine...

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Bibliographic Details
Main Authors: Jaisalmer de Frutos Lucas, Kelsey R. Sewell, Alejandra García-Colomo, Shaun Markovic, Kirk I. Erickson, Belinda M. Brown
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
APOE ε4
Alzheimer’s disease
Physical activity
Amyloid pathology
Tau pathology
Cerebrovascular health
Online Access:https://doi.org/10.1186/s13195-023-01170-4

Internet

https://doi.org/10.1186/s13195-023-01170-4

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