Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route
The aim of this work was the synthesis of hybrid materials of iron (II)-based therapeutic systems via the sol-gel method. Increasing amounts of polyethylene glycol (PEG 6, 12, 24, 50 wt%) were added to SiO<sub>2</sub>/Fe20 wt% to modulate the release kinetics of the drug from the systems...
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MDPI AG
2021-10-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/19/9311 |
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| author | Michelina Catauro Ylenia D’Errico Antonio D’Angelo Ronald J. Clarke Ignazio Blanco |
| author_facet | Michelina Catauro Ylenia D’Errico Antonio D’Angelo Ronald J. Clarke Ignazio Blanco |
| author_sort | Michelina Catauro |
| collection | DOAJ |
| description | The aim of this work was the synthesis of hybrid materials of iron (II)-based therapeutic systems via the sol-gel method. Increasing amounts of polyethylene glycol (PEG 6, 12, 24, 50 wt%) were added to SiO<sub>2</sub>/Fe20 wt% to modulate the release kinetics of the drug from the systems. Fourier-transform infrared (FTIR) spectroscopy was used to study the interactions between different components in the hybrid materials. The release kinetics in a simulated body fluid (SBF) were investigated, and the amount of Fe<sup>2+</sup> released was detected via ultraviolet-visible spectroscopy (UV-Vis) after reaction with ortho-phenanthroline. Furthermore, biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated via the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using spectroscopy. Finally, the potential antibacterial properties of seven different materials against two different bacteria—<i>E. coli</i> and <i>S. aureus</i>—were investigated. |
| first_indexed | 2024-03-10T07:06:04Z |
| format | Article |
| id | doaj.art-c41ee696940d44bc8e920021384b177e |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T07:06:04Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj.art-c41ee696940d44bc8e920021384b177e2023-11-22T15:50:50ZengMDPI AGApplied Sciences2076-34172021-10-011119931110.3390/app11199311Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel RouteMichelina Catauro0Ylenia D’Errico1Antonio D’Angelo2Ronald J. Clarke3Ignazio Blanco4Department of Engineering, University of Campania “Luigi Vanvitelli”, Via Roma 29, 813031 Aversa, ItalyDepartment of Engineering, University of Campania “Luigi Vanvitelli”, Via Roma 29, 813031 Aversa, ItalyDepartment of Engineering, University of Campania “Luigi Vanvitelli”, Via Roma 29, 813031 Aversa, ItalySchool of Chemistry, University of Sydney, Eastern Avenue, Sydney, NSW 2006, AustraliaDepartment of Civil Engineering and Architecture and UdR-Catania Consorzio INSTM, University of Catania, 6 Viale Andrea Doria, 95125 Catania, ItalyThe aim of this work was the synthesis of hybrid materials of iron (II)-based therapeutic systems via the sol-gel method. Increasing amounts of polyethylene glycol (PEG 6, 12, 24, 50 wt%) were added to SiO<sub>2</sub>/Fe20 wt% to modulate the release kinetics of the drug from the systems. Fourier-transform infrared (FTIR) spectroscopy was used to study the interactions between different components in the hybrid materials. The release kinetics in a simulated body fluid (SBF) were investigated, and the amount of Fe<sup>2+</sup> released was detected via ultraviolet-visible spectroscopy (UV-Vis) after reaction with ortho-phenanthroline. Furthermore, biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated via the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using spectroscopy. Finally, the potential antibacterial properties of seven different materials against two different bacteria—<i>E. coli</i> and <i>S. aureus</i>—were investigated.https://www.mdpi.com/2076-3417/11/19/9311ferrous citratesol-gel techniqueFTIR spectroscopyantibacterial activity |
| spellingShingle | Michelina Catauro Ylenia D’Errico Antonio D’Angelo Ronald J. Clarke Ignazio Blanco Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route Applied Sciences ferrous citrate sol-gel technique FTIR spectroscopy antibacterial activity |
| title | Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route |
| title_full | Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route |
| title_fullStr | Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route |
| title_full_unstemmed | Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route |
| title_short | Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route |
| title_sort | antibacterial activity and iron release of organic inorganic hybrid biomaterials synthesized via the sol gel route |
| topic | ferrous citrate sol-gel technique FTIR spectroscopy antibacterial activity |
| url | https://www.mdpi.com/2076-3417/11/19/9311 |
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