Epilepsy, gut microbiota, and circadian rhythm
In recent years, relevant studies have found changes in gut microbiota (GM) in patients with epilepsy. In addition, impaired sleep and circadian patterns are common symptoms of epilepsy. Moreover, the types of seizures have a circadian rhythm. Numerous reports have indicated that the GM and its meta...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1157358/full |
| _version_ | 1797824199345045504 |
|---|---|
| author | Yao Wang Zhihong Zhuo Zhihong Zhuo Zhihong Zhuo Huaili Wang Huaili Wang Huaili Wang |
| author_facet | Yao Wang Zhihong Zhuo Zhihong Zhuo Zhihong Zhuo Huaili Wang Huaili Wang Huaili Wang |
| author_sort | Yao Wang |
| collection | DOAJ |
| description | In recent years, relevant studies have found changes in gut microbiota (GM) in patients with epilepsy. In addition, impaired sleep and circadian patterns are common symptoms of epilepsy. Moreover, the types of seizures have a circadian rhythm. Numerous reports have indicated that the GM and its metabolites have circadian rhythms. This review will describe changes in the GM in clinical and animal studies under epilepsy and circadian rhythm disorder, respectively. The aim is to determine the commonalities and specificities of alterations in GM and their impact on disease occurrence in the context of epilepsy and circadian disruption. Although clinical studies are influenced by many factors, the results suggest that there are some commonalities in the changes of GM. Finally, we discuss the links among epilepsy, gut microbiome, and circadian rhythms, as well as future research that needs to be conducted. |
| first_indexed | 2024-03-13T10:35:25Z |
| format | Article |
| id | doaj.art-c4218bd6866a47e6bdae3639fff532ac |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T10:35:25Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c4218bd6866a47e6bdae3639fff532ac2023-05-18T06:15:47ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-05-011410.3389/fneur.2023.11573581157358Epilepsy, gut microbiota, and circadian rhythmYao Wang0Zhihong Zhuo1Zhihong Zhuo2Zhihong Zhuo3Huaili Wang4Huaili Wang5Huaili Wang6Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Childhood Epilepsy and Immunology, Zhengzhou, ChinaHenan Provincial Children's Neurological Disease Clinical Diagnosis and Treatment Center, Zhengzhou, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Childhood Epilepsy and Immunology, Zhengzhou, ChinaHenan Provincial Children's Neurological Disease Clinical Diagnosis and Treatment Center, Zhengzhou, ChinaIn recent years, relevant studies have found changes in gut microbiota (GM) in patients with epilepsy. In addition, impaired sleep and circadian patterns are common symptoms of epilepsy. Moreover, the types of seizures have a circadian rhythm. Numerous reports have indicated that the GM and its metabolites have circadian rhythms. This review will describe changes in the GM in clinical and animal studies under epilepsy and circadian rhythm disorder, respectively. The aim is to determine the commonalities and specificities of alterations in GM and their impact on disease occurrence in the context of epilepsy and circadian disruption. Although clinical studies are influenced by many factors, the results suggest that there are some commonalities in the changes of GM. Finally, we discuss the links among epilepsy, gut microbiome, and circadian rhythms, as well as future research that needs to be conducted.https://www.frontiersin.org/articles/10.3389/fneur.2023.1157358/fullepilepsygut microbiotacircadian rhythmmicrobiota–gut–brain axisketogenic diet |
| spellingShingle | Yao Wang Zhihong Zhuo Zhihong Zhuo Zhihong Zhuo Huaili Wang Huaili Wang Huaili Wang Epilepsy, gut microbiota, and circadian rhythm Frontiers in Neurology epilepsy gut microbiota circadian rhythm microbiota–gut–brain axis ketogenic diet |
| title | Epilepsy, gut microbiota, and circadian rhythm |
| title_full | Epilepsy, gut microbiota, and circadian rhythm |
| title_fullStr | Epilepsy, gut microbiota, and circadian rhythm |
| title_full_unstemmed | Epilepsy, gut microbiota, and circadian rhythm |
| title_short | Epilepsy, gut microbiota, and circadian rhythm |
| title_sort | epilepsy gut microbiota and circadian rhythm |
| topic | epilepsy gut microbiota circadian rhythm microbiota–gut–brain axis ketogenic diet |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1157358/full |
| work_keys_str_mv | AT yaowang epilepsygutmicrobiotaandcircadianrhythm AT zhihongzhuo epilepsygutmicrobiotaandcircadianrhythm AT zhihongzhuo epilepsygutmicrobiotaandcircadianrhythm AT zhihongzhuo epilepsygutmicrobiotaandcircadianrhythm AT huailiwang epilepsygutmicrobiotaandcircadianrhythm AT huailiwang epilepsygutmicrobiotaandcircadianrhythm AT huailiwang epilepsygutmicrobiotaandcircadianrhythm |