Discovery, Characterization, and Pharmaceutical Applications of Two Loratadine–Oxalic Acid Cocrystals

Discovery, Characterization, and Pharmaceutical Applications of Two Loratadine–Oxalic Acid Cocrystals

Loratadine (Lor) is an antihistamine drug commonly used to relieve the symptoms of allergy. It has high permeability but low solubility under physiological conditions. To overcome the problem of low solubility, we synthesized and characterized two Loratadine multi-component crystalline phases with o...

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Bibliographic Details
Main Authors: Zhengxuan Liang, Hongbo Chen, Chenguang Wang, Changquan Calvin Sun
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Crystals
Subjects:
cocrystal
Loratadine
solubility
intrinsic dissolution rate
compression
Online Access:https://www.mdpi.com/2073-4352/10/11/996

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